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Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
- Source :
- eLife, Vol 9 (2020), eLife
- Publication Year :
- 2020
- Publisher :
- eLife Sciences Publications, Ltd, 2020.
-
Abstract
- Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizing triggered photoreceptor ablation have shown adaptive responses in bipolar cells expected to support normal vision. Whether such homeostatic plasticity occurs during progressive photoreceptor degenerative disease to help maintain normal visual behavior is unknown. We addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H mutation in rhodopsin. We show robust modulation of the retinal transcriptomic network, reminiscent of the neurodevelopmental state, and potentiation of rod – rod bipolar cell signaling following rod photoreceptor degeneration. Additionally, we found highly sensitive night vision in P23H mice even when more than half of the rod photoreceptors were lost. These results suggest retinal adaptation leading to persistent visual function during photoreceptor degenerative disease.
- Subjects :
- Male
0301 basic medicine
Retinal degeneration
retina
Mouse
genetic structures
Mice
chemistry.chemical_compound
0302 clinical medicine
Degenerative disease
Homeostatic plasticity
Biology (General)
Cells, Cultured
Neuronal Plasticity
General Neuroscience
General Medicine
eye
Retinal adaptation
medicine.anatomical_structure
sensory systems
Medicine
Female
Retinitis Pigmentosa
Research Article
Retinal Bipolar Cells
Rhodopsin
vision
QH301-705.5
Science
Biology
General Biochemistry, Genetics and Molecular Biology
homeostatic plasticity
03 medical and health sciences
Night vision
Retinitis pigmentosa
medicine
Animals
Night Vision
Retina
General Immunology and Microbiology
Retinal
medicine.disease
eye diseases
Mice, Inbred C57BL
030104 developmental biology
chemistry
Mutation
retinal degeneration
sense organs
Transcriptome
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2050084X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....2d8b95543cec8a8291eea9a1221a70a5
- Full Text :
- https://doi.org/10.7554/elife.59422