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Exposure to a context previously associated with nausea elicits conditioned gaping in rats: A model of anticipatory nausea
- Source :
- Behavioural Brain Research. 187:33-40
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Following one or more chemotherapy treatments, many patients report that they experience anticipatory nausea. This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting that developed following treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed a flavored solution previously paired with a toxin. Here we report that, even in the absence of a flavored solution, rats display conditioned gaping reactions during exposure to a distinctive context previously paired with a high dose of lithium (Experiment 1 with a distinctive odor and Experiment 3 without a distinctive odor), a low dose of lithium (Experiment 2) or provocative vestibular stimulation (Experiment 2). These results suggest that the conditioned gaping reaction in rats is selectively elicited by nausea-paired contextual stimuli, as well as flavors. This rat model of anticipatory nausea may serve as a valuable preclinical tool to evaluate the effectiveness of anti-nausea treatments and the side effect of nausea produced by newly developed pharmaceutical compounds intended for other clinical treatments.
- Subjects :
- Male
Rotation
Lithium (medication)
Side effect
Motion Sickness
medicine.drug_class
Nausea
medicine.medical_treatment
Conditioning, Classical
Context (language use)
Pharmacology
Rats, Sprague-Dawley
Behavioral Neuroscience
Physical Stimulation
medicine
Animals
Chemotherapy
Behavior, Animal
Mood stabilizer
Rats
Odor
Data Interpretation, Statistical
Taste
Odorants
Vomiting
Vestibule, Labyrinth
Vomiting, Anticipatory
Cues
medicine.symptom
Lithium Chloride
Psychology
Social psychology
medicine.drug
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 187
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....2d8d7969f7f2667c0a27fc867486f8a5