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Prospective Study on Incidence, Risk Factors and Outcome of Recurrent
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 1127, p 1127 (2021), Volume 10, Issue 5
- Publication Year :
- 2020
-
Abstract
- Background: Limited and wide-ranging data are available on the recurrent Clostridioides difficile infection (rCDI) incidence rate. Methods: We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case–control study was performed to identify risk factors associated with 30-day onset rCDI. Results: Three hundred nine patients with a first CDI were included in the study<br />32% of the CDI episodes (99/309) were severe/complicated<br />complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up<br />rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR: 1.7<br />95% CI: 1.1–2.7, p = 0.03). Conclusion: Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.
- Subjects :
- medicine.medical_specialty
recurrence
genetic structures
lcsh:Medicine
Logistic regression
Clostridioides difficile
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
risk factors
030212 general & internal medicine
Risk factor
Prospective cohort study
0303 health sciences
Adult patients
030306 microbiology
business.industry
Incidence (epidemiology)
Mortality rate
lcsh:R
General Medicine
risk factor
outcome
incidence
business
Clostridioides
Cohort study
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of clinical medicine
- Accession number :
- edsair.doi.dedup.....2d9ba7a237b5f07dbcaa745d6c869242