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Author Correction: Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
- Source :
- Nature Communications, Nature Communications, Vol 10, Iss 1, Pp 1-3 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10−8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10−17), 6q23.3 (rs6928977, P = 4.62 × 10−11), 10p14 (rs3781093, P = 9.49 × 10−13), 13q34 (rs112998813, P = 4.58 × 10−8) and 16p13.13 (rs34972832, P = 2.12 × 10−8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.<br />Classical Hodgkin lymphoma is a cancer that originates in lymph nodes. Little is known about its genetic susceptibility. Here, the authors combined existing and new genome-wide association studies to identify risk loci for classical Hodgkin lymphoma at 6q22.33, and nodular sclerosis Hodgkin lymphoma at 3q28, 6q23.3, 10p14, 13q34, 16p13.13.
- Subjects :
- Science
Medizin
MEDLINE
General Physics and Astronomy
Genome-wide association study
Computational biology
Polymorphism, Single Nucleotide
Article
General Biochemistry, Genetics and Molecular Biology
Disease susceptibility
immune system diseases
hemic and lymphatic diseases
Classical Hodgkin lymphoma
Humans
Genetic Predisposition to Disease
Author Correction
lcsh:Science
Alleles
HLA-DP beta-Chains
Multidisciplinary
Published Erratum
General Chemistry
Hodgkin Disease
Spelling
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Key (cryptography)
lcsh:Q
Psychology
Genome-Wide Association Study
HLA-DRB1 Chains
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....2d9e938f3c37cc42eb72319b9ab6ef06