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Cutaneous T cell lymphoma with suppressor phenotype and function
- Source :
- Southern medical journal. 82(4)
- Publication Year :
- 1989
-
Abstract
- Cutaneous T cell lymphomas (CTCL) are typically malignancies of postthymic helper T cells which retain helper function when assayed in vitro. We have described a case clinically and morphologically consistent with CTCL, but in which the tumor cells unequivocally had a suppressor T cell phenotype and suppressor function. This case could be differentiated from other varieties of peripheral T cell lymphomas by multiple clinical and laboratory parameters. The increasingly routine use of immune phenotyping in the evaluation of malignant lymphomas will likely result in the identification of additional cases of this entity, which should be studied to assess its clinical and prognostic relationship to the more common helper cell CTCL.
- Subjects :
- Male
Skin Neoplasms
Lymphoma
business.industry
T cell
Cutaneous T-cell lymphoma
Cell
General Medicine
Middle Aged
medicine.disease
Phenotype
T-Lymphocytes, Regulatory
In vitro
law.invention
medicine.anatomical_structure
Immune system
law
hemic and lymphatic diseases
medicine
Cancer research
Suppressor
Humans
business
Function (biology)
Subjects
Details
- ISSN :
- 00384348
- Volume :
- 82
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Southern medical journal
- Accession number :
- edsair.doi.dedup.....2da5b489aeffcb2dea94036fb58be7d6