Back to Search
Start Over
Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
- Source :
- eLife, Vol 10 (2021), Milne, K, Ivens, A, Reid, A J, Lotkowska, M E, O'Toole, Á, Sankaranarayanan, G, Munoz Sandoval, D, Nahrendorf, W, Regnault, C, Edwards, N J, Silk, S E, Payne, R O, Minassian, A M, Venkatraman, N, Sanders, M, Hill, A V S, Barrett, M P, Berriman, M, Draper, S J, Rowe, A J & Spence, P J 2021, ' Mapping immune variation and var gene switching in naïve hosts infected with Plasmodium falciparum ', eLIFE, vol. 10, e62800 . https://doi.org/10.7554/eLife.62800
- Publication Year :
- 2021
- Publisher :
- eLife Sciences Publications Ltd, 2021.
-
Abstract
- Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variation observed in controlled human malaria infection (CHMI). We uncovered marked heterogeneity in the host response to blood challenge; some volunteers remained quiescent, others triggered interferon-stimulated inflammation and some showed transcriptional evidence of myeloid cell suppression. Significantly, only inflammatory volunteers experienced hallmark symptoms of malaria. When we tracked temporal changes in parasite VSA expression to ask whether variants associated with severe disease rapidly expand in naive hosts, we found no transcriptional evidence to support this hypothesis. These data indicate that parasite variants that dominate severe malaria do not have an intrinsic growth or survival advantage; instead, they presumably rely upon infection-induced changes in their within-host environment for selection.
- Subjects :
- Myeloid
QH301-705.5
Science
Inflammation
systems immunology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
var gene switching
parasitic diseases
medicine
Parasite hosting
Biology (General)
030304 developmental biology
0303 health sciences
General Immunology and Microbiology
biology
General Neuroscience
Plasmodium falciparum
General Medicine
biology.organism_classification
medicine.disease
metabolomics
3. Good health
medicine.anatomical_structure
human immune variation
Infectious disease (medical specialty)
inflammation
Immunology
falciparum malaria
Medicine
medicine.symptom
030217 neurology & neurosurgery
Malaria
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....2dabfbdeab670e7303331411e94d6707