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Advances in the Diagnosis and Treatment of Neuroblastoma
Advances in the Diagnosis and Treatment of Neuroblastoma
- Source :
- The Oncologist. 8:278-292
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- Learning Objectives After completing this course, the reader will be able to: Appreciate the heterogeneity of neuroblastoma and identify clinical and biological prognostic factors. Explain the determinants and the clinical significance of the neuroblastoma risk stratification system. Select appropriate treatment regimens for neuroblastoma patients that are tailored according to risk stratification. Access and take the CME test online and receive one hour of AMA PRA category 1 credit at CME.TheOncologist.com Neuroblastoma, a childhood neoplasm arising from neural crest cells, is characterized by a diversity of clinical behavior ranging from spontaneous remission to rapid tumor progression and death. To a large extent, outcome can be predicted by the stage of disease and the age at diagnosis. However, the molecular events responsible for the variability in response to treatment and the rate of tumor growth remain largely unknown. Over the past decade, transformation-linked genetic changes have been identified in neuroblastoma tumors that have contributed to the understanding of tumor predisposition, metastasis, treatment responsiveness, and prognosis. The Children's Oncology Group recently developed a Neuroblastoma Risk Stratification System that is currently in use for treatment stratification purposes, based on clinical and biologic factors that are strongly predictive of outcome. This review discusses the current risk-based treatment approaches for children with neuroblastoma and recent advances in biologic therapy.
- Subjects :
- Adult
Oncology
Cancer Research
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Child Welfare
Spontaneous remission
Disease
Metastasis
Neuroblastoma
Internal medicine
medicine
Humans
Stage (cooking)
Child
Neoplasm Staging
Brain Neoplasms
business.industry
Incidence
Infant Welfare
Infant, Newborn
Infant
Immunotherapy
medicine.disease
United States
Childhood Neoplasm
Tumor progression
Child, Preschool
Immunology
Disease Progression
business
Subjects
Details
- ISSN :
- 1549490X and 10837159
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- The Oncologist
- Accession number :
- edsair.doi.dedup.....2de831b89fa03d1895066ce36a33b300
- Full Text :
- https://doi.org/10.1634/theoncologist.8-3-278