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Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
- Source :
- Human Molecular Genetics, Human Molecular Genetics, Oxford University Press (OUP), 2014, 23 (16), pp.4420-32. ⟨10.1093/hmg/ddu139⟩, Human Molecular Genetics, 23(16), 4420-4432. Oxford University Press, Human Molecular Genetics; Vol 23, Hum Mol Genet, Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Guðbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Anderson-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F-A, Hottenga, J-J, Hofman, A, Juene, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, Mcnerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Rea, I M, Passarino, G, de Craen, A J M, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 6, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139, Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Guðbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Andersen-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F-A, Hottenga, J-J, Hofman, A, Jeune, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Rea, I M, Passarino, G, de Craen, A J M, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 16, ddu139, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139, Human Molecular Genetics, 23(16), 4420-4432, Deelen, J, Beekman, M, Uh, H W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Gudbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Andersen-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F A, Hottenga, J J, Hofman, A, Jeune, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefansson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Maeve Rea, I, Passarino, G, de Craen, A J, Christensen, K, Nebel, A, Stefansson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 16, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (
- Subjects :
- Male
Netherlands Twin Register (NTR)
Disease/genetics
Lífslíkur
Longevity/genetics
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Genetic Linkage
Genome-wide association study
0302 clinical medicine
Prospective Studies
Genetics (clinical)
Genetics
Aged, 80 and over
0303 health sciences
education.field_of_study
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Association Studies Articles
Age Factors
Chromosome Mapping
Genetic Loci/physiology
General Medicine
3. Good health
Europe
Phenotype
Cardiovascular Diseases
Hypertension
Chromosomes, Human, Pair 5
Female
Human Longevity, genetics, meta-analysis
Aging/genetics
Cardiology and Cardiovascular Medicine
HUMAN AGING
Longevity
European Continental Ancestry Group
Population
HUMAN GENETICS
Single-nucleotide polymorphism
Locus (genetics)
Biology
FAMILIAL LONGEVITY
White People
03 medical and health sciences
Gene mapping
SDG 3 - Good Health and Well-being
Cardiovascular Diseases/genetics
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Humans
Allele
education
Molecular Biology
Aged
030304 developmental biology
Genetic association
Öldrun
Genome, Human
Arfgengi
Minor allele frequency
Ageing
Genetic Loci
Chromosomes, Human, Pair 19
Hypertension/genetics
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20010125, 09646906, and 14602083
- Database :
- OpenAIRE
- Journal :
- Human Molecular Genetics, Human Molecular Genetics, Oxford University Press (OUP), 2014, 23 (16), pp.4420-32. ⟨10.1093/hmg/ddu139⟩, Human Molecular Genetics, 23(16), 4420-4432. Oxford University Press, Human Molecular Genetics; Vol 23, Hum Mol Genet, Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Guðbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Anderson-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F-A, Hottenga, J-J, Hofman, A, Juene, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, Mcnerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Rea, I M, Passarino, G, de Craen, A J M, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 6, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139, Deelen, J, Beekman, M, Uh, H-W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Guðbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Andersen-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F-A, Hottenga, J-J, Hofman, A, Jeune, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefánsson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Rea, I M, Passarino, G, de Craen, A J M, Christensen, K, Nebel, A, Stefánsson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 16, ddu139, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139, Human Molecular Genetics, 23(16), 4420-4432, Deelen, J, Beekman, M, Uh, H W, Broer, L, Ayers, K L, Tan, Q, Kamatani, Y, Bennet, A M, Tamm, R, Trompet, S, Gudbjartsson, D F, Flachsbart, F, Rose, G, Viktorin, A, Fischer, K, Nygaard, M, Cordell, H J, Crocco, P, van den Akker, E B, Böhringer, S, Helmer, Q, Nelson, C P, Saunders, G I, Alver, M, Andersen-Ranberg, K, Breen, M E, van der Breggen, R, Caliebe, A, Capri, M, Cevenini, E, Collerton, J C, Dato, S, Davies, K, Ford, I, Gampe, J, Garagnani, P, de Geus, E J C, Harrow, J, van Heemst, D, Heijmans, B T, Heinsen, F A, Hottenga, J J, Hofman, A, Jeune, B, Jonsson, P V, Lathrop, M, Lechner, D, Martin-Ruiz, C, McNerlan, S E, Mihailov, E, Montesanto, A, Mooijaart, S P, Murphy, A, Nohr, E A, Paternoster, L, Postmus, I, Rivadeneira, F, Ross, O A, Salvioli, S, Sattar, N, Schreiber, S, Stefansson, H, Stott, D J, Tiemeier, H, Uitterlinden, A G, Westendorp, R G J, Willemsen, G, Samani, N J, Galan, P, Sørensen, T I A, Boomsma, D I, Jukema, J W, Maeve Rea, I, Passarino, G, de Craen, A J, Christensen, K, Nebel, A, Stefansson, K, Metspalu, A, Magnusson, P, Blanché, H, Christiansen, L, Kirkwood, T B L, van Duijn, C M, Franceschi, C, Houwing-Duistermaat, J J & Slagboom, P E 2014, ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ', Human Molecular Genetics, vol. 23, no. 16, pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139
- Accession number :
- edsair.doi.dedup.....2dfb08885308eb13bdb055dbffe5c73e