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Prognostic and predictive value of epigenetic biomarkers and clinical factors in upper tract urothelial carcinoma
- Source :
- Epigenomics. 7:733-744
- Publication Year :
- 2015
- Publisher :
- Future Medicine Ltd, 2015.
-
Abstract
- Aim: We conducted this study to identify gene promoter methylation status and clinical predictors for upper tract urothelial carcinoma (UTUC) patients. Materials & methods: Using methylation-sensitive PCR, we examined ten genes promoter methylation status in 687 UTUC patients. Results: A methylated promoter of three genes to predict higher tumor stage (T3 and T4), five genes to predict higher tumor grade (G3) and one gene to predict pN+ were certified in this study. Nine factors were significantly associated with poor cancer-specific survival. Six factors were considered as predictors to develop bladder recurrence after surgery. Conclusion: Methylation occurs commonly in UTUCs, may affect carcinogenic mechanisms, and is a well predictive factor for cancer-specific survival and bladder recurrence in UTUCs.
- Subjects :
- Adult
Male
Oncology
Urologic Neoplasms
Cancer Research
medicine.medical_specialty
Biology
Disease-Free Survival
Young Adult
Predictive Value of Tests
Risk Factors
Internal medicine
Biomarkers, Tumor
Genetics
medicine
Humans
Promoter Regions, Genetic
Gene
Aged
Neoplasm Staging
Urothelial carcinoma
Aged, 80 and over
Epigenetic biomarkers
Carcinoma, Transitional Cell
Promoter
Methylation
DNA Methylation
Middle Aged
Nomogram
Prognosis
Predictive value
Logistic Models
Urinary Bladder Neoplasms
Upper tract
Multivariate Analysis
Female
Neoplasm Recurrence, Local
Subjects
Details
- ISSN :
- 1750192X and 17501911
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Epigenomics
- Accession number :
- edsair.doi.dedup.....2dffbf19d13a5ea3cba71f764abe625f