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A characterization of cortisol level and adrenal reservation in human cardiopulmonary arrest: systematic review and meta-analysis
- Source :
- Systematic Reviews, Vol 10, Iss 1, Pp 1-8 (2021), Systematic Reviews
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients. Methods We searched the following databases: PubMed, Scopus, ISI Web of Science, and Google Scholar. Relevant observational and controlled trials were explored from inception by April 2020. The quality of the articles was assessed using the Newcastle-Ottawa Scale (NOS). Results Finally, five cohort studies (n = 201 participants in total) were eligible for including in the meta-analysis. The results of this meta-analysis showed that although the baseline serum cortisol levels were higher in survivors of cardiac arrest compared with non-survivors, the differences between groups do not reach a significance level (Hedges’ g = 0.371, 95% CI, −0.727, 1.469, P value = 0.508). Between-study heterogeneity was statistically significant (Cochrane Q test: P value < 0.001, I2 = 89.323). Conclusions The result of the present meta-analysis was suggestive of a higher baseline serum cortisol levels in survivors of CPA. Future randomized controlled studies with a large sample size will determine the exact relationship between adrenal reservation and the eventual outcome of patients with CPA. Systematic review registration PROSPERO CRD42018085468
- Subjects :
- Isi web of science
medicine.medical_specialty
Hydrocortisone
business.industry
Research
Cortisol level
Medicine (miscellaneous)
Controlled studies
Cardiac arrest
Heart Arrest
Adrenal reservation
Meta-analysis
Statistical significance
Internal medicine
Systematic review
Medicine
Humans
Observational study
business
Glucocorticoids
Serum cortisol
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20464053
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Systematic Reviews
- Accession number :
- edsair.doi.dedup.....2e1b522857d71ff3115b7ca01e540d00