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Cyclic lipopeptide production by plant-associated Pseudomonas spp.: diversity, activity, biosynthesis, and regulation
- Source :
- Molecular Plant-Microbe Interactions, 19(7), 699-710, Molecular Plant-Microbe Interactions 19 (2006) 7
- Publication Year :
- 2006
-
Abstract
- Cyclic lipopeptides (CLPs) are versatile molecules produced by a variety of bacterial genera, including plant-associated Pseudomonas spp. CLPs are composed of a fatty acid tail linked to a short oligopeptide, which is cyclized to form a lactone ring between two amino acids in the peptide chain. CLPs are very diverse both structurally and in terms of their biological activity. The structural diversity is due to differences in the length and composition of the fatty acid tail and to variations in the number, type, and configuration of the amino acids in the peptide moiety. CLPs have received considerable attention for their antimicrobial, cytotoxic, and surfactant properties. For plant-pathogenic Pseudomonas spp., CLPs constitute important virulence factors, and pore formation, followed by cell lysis, is their main mode of action. For the antagonistic Pseudomonas sp., CLPs play a key role in antimicrobial activity, motility, and biofilm formation. CLPs are produced via nonribosomal synthesis on large, multifunctional peptide synthetases. Both the structural organization of the CLP synthetic templates and the presence of specific domains and signature sequences within peptide synthetase genes will be described for both pathogenic and antagonistic Pseudomonas spp. Finally, the role of various genes and regulatory mechanisms in CLP production by Pseudomonas spp., including two-component regulation and quorum sensing, will be discussed in detail. Additional keywords: Bacillus, nonribosomal peptide synthesis
- Subjects :
- sugar-beet rhizosphere
Physiology
nonribosomal peptide synthetases
Lipoproteins
Peptide
Microbiology
chemistry.chemical_compound
Biosynthesis
Pseudomonas
bacillus-subtilis
Plant Diseases
chemistry.chemical_classification
Oligopeptide
biology
EPS-2
Biofilm
syringae pv.-syringae
General Medicine
Gene Expression Regulation, Bacterial
Plants
biology.organism_classification
Amino acid
gene-cluster
Laboratorium voor Phytopathologie
Quorum sensing
chemistry
Biochemistry
brown blotch disease
Laboratory of Phytopathology
biofilm formation
channel-forming activities
sp strain dss73
Agronomy and Crop Science
Pseudomonadaceae
fluorescens dr54
Subjects
Details
- ISSN :
- 08940282
- Volume :
- 19
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Molecular plant-microbe interactions : MPMI
- Accession number :
- edsair.doi.dedup.....2e343031834e48d45cfe047c07810ca0