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Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex

Authors :
Felix M. Paulussen
Gina K. Schouten
Carolin Moertl
Jolanda Verheul
Irma Hoekstra
Gregory M. Koningstein
George H. Hutchins
Aslihan Alkir
Rosa A. Luirink
Daan P. Geerke
Peter van Ulsen
Tanneke den Blaauwen
Joen Luirink
Tom N. Grossmann
Source :
Journal of the American Chemical Society. 144(33)
Publication Year :
2022

Abstract

The use of antibiotics is threatened by the emergence and spread of multidrug-resistant strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In this respect, the bacterial divisome, a multi-protein complex central to cell division, represents a potentially attractive target. Of particular interest is the FtsQB subcomplex that plays a decisive role in divisome assembly and peptidoglycan biogenesis in

Details

ISSN :
15205126
Volume :
144
Issue :
33
Database :
OpenAIRE
Journal :
Journal of the American Chemical Society
Accession number :
edsair.doi.dedup.....2e3c685c7ec6cad6f37fb845aeb2ae85