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Control of bone and fat mass by oxytocin
- Source :
- Hormone Molecular Biology and Clinical Investigation, Hormone Molecular Biology and Clinical Investigation, de Gruyter, 2016, 28 (2), pp.95-104. ⟨10.1515/hmbci-2016-0045⟩, Hormone Molecular Biology and Clinical Investigation, 2016, 28 (2), pp.95-104. ⟨10.1515/hmbci-2016-0045⟩
- Publication Year :
- 2016
-
Abstract
- Osteoporosis and overweight/obesity constitute major worldwide public health burdens. Aging is associated with a decrease in hormonal secretion, lean mass and bone mass, and an increase in fat accumulation. It is established that both obesity and osteoporosis are affected by genetic and environmental factors, bone remodeling and adiposity are both regulated through the hypothalamus and sympathetic nervous system. Oxytocin (OT), belongs to the pituitary hormone family and regulates the function of peripheral target organs, its circulating levels decreased with age. Nowadays, it is well established that OT plays an important role in the control of bone and fat mass and their metabolism. Of note, OT and oxytocin receptor knock out mice develop bone defects and late-onset obesity. Thus OT emerges as a promising molecule in the treatment of osteoporosis and obesity as well as associated metabolic disorders such as type 2 diabetes and cardiovascular diseases. In this review, we will discuss findings regarding the OT effects on bone and fat mass.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Osteoporosis
Type 2 diabetes
Overweight
Oxytocin
Bone and Bones
Bone remodeling
03 medical and health sciences
chemistry.chemical_compound
Mice
Endocrinology
Adipocyte
Internal medicine
Oxytocics
[SDV.BDD] Life Sciences [q-bio]/Development Biology
medicine
MESH: Oxytocin
Animals
Humans
MESH: Animals
Molecular Biology
MESH: Mice
[SDV.BDD]Life Sciences [q-bio]/Development Biology
MESH: Humans
business.industry
MESH: Oxytocics
General Medicine
MESH: Bone and Bones
medicine.disease
Obesity
Oxytocin receptor
3. Good health
030104 developmental biology
chemistry
Adipose Tissue
medicine.symptom
business
MESH: Adipose Tissue
medicine.drug
MESH: Osteoporosis
Subjects
Details
- ISSN :
- 18681891 and 18681883
- Volume :
- 28
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Hormone molecular biology and clinical investigation
- Accession number :
- edsair.doi.dedup.....2e53534721ee6f227c03e6b0e0a69ce2