Back to Search
Start Over
Wheat straw extracted lignin in silver nanoparticles synthesis: Expanding its prophecy towards antineoplastic potency and hydrogen peroxide sensing ability
- Source :
- International journal of biological macromolecules. 128
- Publication Year :
- 2018
-
Abstract
- Lignin, is the most abundant, renewable and degradable biopolymer available in the nature. The present study exploited purified lignin from wheat straw as reducing, capping and stabilizing agent for the green synthesis of silver nanoparticles (Li-AgNPs) under optimized conditions. The analytical studies revealed synthesized Li-AgNPs having a face centered cubic crystalline structure, size ranging ~15–20 nm and the biomolecules comprising majorly phenolic, hydroxyl and carboxylic group of lignin coated on the surface of AgNPs. Li-AgNPs showed significant antimicrobial efficacy against human pathogens namely; Staphylococcus aureus and Escherichia coli and also determined their minimum inhibitory and minimum bactericidal concentration (MIC and MBC). Li-AgNPs also displayed substantial antioxidant activity in terms of well-known enzyme marker viz.; ABTS and DPPH free radical scavenging assay relative to commercial AgNPs. In vitro cytotoxicity assay of Li-AgNPs demonstrated dose-dependent toxicity effects in SKOV3 ovarian cancer cell line (LD50; 150 μg/mL) indicative of promising anticancer agent. Further, H2O2 sensing ability of stabilized Li-AgNPs exhibited its vital role in determining reactive oxygen species. Synthesis of Li-AgNPs is a cheap green technology and could exhibit its commercial use in biomedical, cosmetic, and pharmaceutical industry.
- Subjects :
- Staphylococcus aureus
Antioxidant
Silver
DPPH
medicine.medical_treatment
Metal Nanoparticles
Antineoplastic Agents
02 engineering and technology
engineering.material
Biochemistry
Lignin
Silver nanoparticle
03 medical and health sciences
chemistry.chemical_compound
Picrates
Structural Biology
Cell Line, Tumor
medicine
Escherichia coli
Humans
Benzothiazoles
Hydrogen peroxide
Molecular Biology
Triticum
030304 developmental biology
0303 health sciences
ABTS
Minimum bactericidal concentration
Biphenyl Compounds
Green Chemistry Technology
General Medicine
Free Radical Scavengers
Hydrogen Peroxide
021001 nanoscience & nanotechnology
Anti-Bacterial Agents
chemistry
engineering
Biopolymer
Sulfonic Acids
0210 nano-technology
Nuclear chemistry
Subjects
Details
- ISSN :
- 18790003
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- International journal of biological macromolecules
- Accession number :
- edsair.doi.dedup.....2e653fb67c37a74bfbb43fe58eb78ccd