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Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
- Source :
- The American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University press, Am. J. Clin. Nutr. 93, 851-860 (2011), American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University Press, Kilpelaeinen, T O, den Hoed, M, Ong, K K, Grontved, A, Brage, S, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J, Loos, R J F & Early Growth Genetics, C 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828, Kilpelaïnen, T O, van den Hoed, M, Ong, K K, Grøntved, A, Brage, S, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J & Loos, R J 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', The American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828
- Publication Year :
- 2011
-
Abstract
- Background: High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background. Objective: The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight. Design: A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (n(max) = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (n(max) = 10,623); and 3) all published data (n(max) = 14,837). Results: Only the MTCH2 and FTO loci showed a nominally significant association with birth weight. The BMI-increasing allele of the MTCH2 variant (rs10838738) was associated with a lower birth weight (beta +/- SE: 213 +/- 5 g/allele; P = 0.012; n = 23,680), and the BMI-increasing allele of the FTO variant (rs1121980) was associated with a higher birth weight (beta +/- SE: 11 +/- 4 g/allele; P = 0.013; n = 28,219). These results were not significant after correction for multiple testing. Conclusions: Obesity-susceptibility loci have a small or no effect on weight at birth. Some evidence of an association was found for the MTCH2 and FTO loci, ie, lower and higher birth weight, respectively. These findings may provide new insights into the underlying mechanisms by which these loci confer an increased risk of obesity. Am J Clin Nutr 2011;93:851-60.
- Subjects :
- Male
Netherlands Twin Register (NTR)
obesity
Medicine (miscellaneous)
Genome-wide association study
MC4R
Mitochondrial Membrane Transport Proteins
FTO gene
Body Mass Index
ADULT OBESITY
Birth Weight
body mass index (BMI)
GESTATIONAL-AGE
Aged, 80 and over
Genetics
Nutrition and Dietetics
Middle Aged
European Prospective Investigation into Cancer and Nutrition
FAT MASS
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
loci
Genome-wide association
Body-mass index
Gestational-age
Common variant
Adult obesity
Fetal-growth
Fat mass
Adiposity
Female
Adult
medicine.medical_specialty
Birth weight
Biology
Mitochondrial Proteins
Young Adult
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Humans
COHORT
Obesity
GENOME-WIDE ASSOCIATION
Allele
FTO GENE
Alleles
Aged
Membrane Transport Proteins
Proteins
birth weight
medicine.disease
COMMON VARIANT
BODY-MASS INDEX
Endocrinology
Genetic Loci
FETAL-GROWTH
Body mass index
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University press, Am. J. Clin. Nutr. 93, 851-860 (2011), American Journal of Clinical Nutrition, 93(4), 851-860. Oxford University Press, Kilpelaeinen, T O, den Hoed, M, Ong, K K, Grontved, A, Brage, S, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J, Loos, R J F & Early Growth Genetics, C 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828, Kilpelaïnen, T O, van den Hoed, M, Ong, K K, Grøntved, A, Brage, S, Hottenga, J J, Willemsen, G, de Geus, E J C, Boomsma, D I, Jameson, K, Cooper, C, Khaw, K T, Ekelund, U, Wareham, N J & Loos, R J 2011, ' Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals ', The American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860 . https://doi.org/10.3945/ajcn.110.000828
- Accession number :
- edsair.doi.dedup.....2e768ebd60ee8cc17d2967cd4177757c