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Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic β2 receptor in a Swedish hypertensive population
- Source :
- Journal of Human Hypertension. 19:705-708
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- The Arg16Gly and the Gln27Glu polymorphisms in the gene for the beta2-adrenergic receptor (beta2AR) have been linked to an increased risk for cardiovascular disease. The aim of the present study was to evaluate the significance of these haplotypes for development of myocardial infarction (MI) as well as other cardiovascular phenotypes. In a prospective study cohort (CAPPP), 522 hypertensive patients (174 MI and 348 matched controls) were analysed for the Arg16Gly and the Gln27Glu polymorphisms by dynamic allele-specific hybridisation. The haplotype could successfully be determined in 516 patients. Haplotype was not significantly associated with MI. Systolic blood pressure (SBP) was higher in patients with Arg16Gly+Gln27Gln and lower in patients with Arg16Gly+Gln27Glu as compared with the other haplotypes. Haplotype was not associated with body mass index, diastolic blood pressure, cholesterol, LDL, HDL triglycerides or a diagnosis of diabetes mellitus. The present study found no evidence that haplotype for the two most common polymorphisms in the beta2AR are associated with development of MI in a Swedish hypertensive population, but haplotype may be associated with SBP.
- Subjects :
- Male
medicine.medical_specialty
Heart disease
Glutamine
Population
Glycine
Myocardial Infarction
Glutamic Acid
Blood Pressure
Arginine
Cohort Studies
Internal medicine
Diabetes mellitus
Internal Medicine
Humans
Medicine
Prospective Studies
Myocardial infarction
Prospective cohort study
education
Sweden
education.field_of_study
Polymorphism, Genetic
business.industry
Haplotype
Middle Aged
medicine.disease
Endocrinology
Blood pressure
Haplotypes
Hypertension
Female
Receptors, Adrenergic, beta-2
business
Body mass index
Subjects
Details
- ISSN :
- 14765527 and 09509240
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Human Hypertension
- Accession number :
- edsair.doi.dedup.....2ea9bdd7956dd5a730ca0778e6cf3a36
- Full Text :
- https://doi.org/10.1038/sj.jhh.1001897