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Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic β2 receptor in a Swedish hypertensive population

Authors :
Thomas Hedner
Anna-Lena Eriksson
Sven Wallerstedt
Claes Ohlsson
Source :
Journal of Human Hypertension. 19:705-708
Publication Year :
2005
Publisher :
Springer Science and Business Media LLC, 2005.

Abstract

The Arg16Gly and the Gln27Glu polymorphisms in the gene for the beta2-adrenergic receptor (beta2AR) have been linked to an increased risk for cardiovascular disease. The aim of the present study was to evaluate the significance of these haplotypes for development of myocardial infarction (MI) as well as other cardiovascular phenotypes. In a prospective study cohort (CAPPP), 522 hypertensive patients (174 MI and 348 matched controls) were analysed for the Arg16Gly and the Gln27Glu polymorphisms by dynamic allele-specific hybridisation. The haplotype could successfully be determined in 516 patients. Haplotype was not significantly associated with MI. Systolic blood pressure (SBP) was higher in patients with Arg16Gly+Gln27Gln and lower in patients with Arg16Gly+Gln27Glu as compared with the other haplotypes. Haplotype was not associated with body mass index, diastolic blood pressure, cholesterol, LDL, HDL triglycerides or a diagnosis of diabetes mellitus. The present study found no evidence that haplotype for the two most common polymorphisms in the beta2AR are associated with development of MI in a Swedish hypertensive population, but haplotype may be associated with SBP.

Details

ISSN :
14765527 and 09509240
Volume :
19
Database :
OpenAIRE
Journal :
Journal of Human Hypertension
Accession number :
edsair.doi.dedup.....2ea9bdd7956dd5a730ca0778e6cf3a36
Full Text :
https://doi.org/10.1038/sj.jhh.1001897