Back to Search
Start Over
Association between Lp-PLA2 and coronary heart disease in Chinese patients
- Source :
- The Journal of International Medical Research
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Objective To evaluate the association between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2; known to release inflammatory mediators that promote atherosclerosis) and coronary heart disease (CHD) in Chinese patients. Methods This observational, cross-sectional study included a patient cohort who were assessed by coronary angiography and divided into patients with coronary heart disease and patients with normal coronary angiography (controls). Data for several biochemical indicators were collected. Plasma Lp-PLA2 concentrations were measured by enzyme-linked immunosorbent assay. Univariate and multivariate logistic regression were used to analyse the association between Lp-PLA2 concentration and CHD. Results A total of 531 patients were included, comprising 391 with CHD and 140 with normal coronary angiography (controls). Plasma Lp-PLA2 concentration was significantly higher in patients with CHD versus controls (median, 251 µg/l versus 219 µg/l, respectively), and particularly among patients with acute myocardial infarction and stable angina pectoris (249 µg/l and 266 µg/l, respectively). Multivariate analysis showed that Lp-PLA2 ≥ 292 µg/l (upper quartile of the whole cohort) was independently associated with CHD (odds ratio 2.814, 95% confidence interval 1.519, 5.214). Conclusion Plasma Lp-PLA2 concentration was independently associated with CHD in Chinese patients.
- Subjects :
- Adult
Male
0301 basic medicine
Coronary angiography
medicine.medical_specialty
Myocardial Infarction
Gene Expression
Coronary Disease
030204 cardiovascular system & hematology
Coronary Angiography
Logistic regression
Biochemistry
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
Humans
Medicine
In patient
Angina, Stable
Myocardial infarction
coronary heart disease
Lipoprotein-associated phospholipase A2
Aged
Aged, 80 and over
Framingham Risk Score
business.industry
Biochemistry (medical)
Research Reports
Cell Biology
General Medicine
Middle Aged
medicine.disease
Coronary heart disease
Cross-Sectional Studies
Logistic Models
030104 developmental biology
1-Alkyl-2-acetylglycerophosphocholine Esterase
Multivariate Analysis
Cohort
Cardiology
lipids (amino acids, peptides, and proteins)
Female
atherosclerosis
business
Biomarkers
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....2ea9c58cbe773d2728d6a0ee0ae2c8d5