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Amylin receptor blockade stimulates food intake in rats
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 287:R568-R574
- Publication Year :
- 2004
- Publisher :
- American Physiological Society, 2004.
-
Abstract
- Amylin is postulated to act as a hormonal signal from the pancreas to the brain to inhibit food intake and regulate energy reserves. Amylin potently reduces food intake, body weight, and adiposity when administered systemically or into the brain. Whether selective blockade of endogenous amylin action increases food intake and adiposity remains to be clearly established. In the present study, the amylin receptor antagonist acetyl-[Asn30, Tyr32] sCT-( 8 – 32 ) (AC187) was used to assess whether action of endogenous amylin is essential for normal satiation to occur. Non-food-deprived rats received a 3- to 4-h intravenous infusion of AC187 (60–2,000 pmol·kg−1·min−1), either alone or coadministered with a 3-h intravenous infusion of amylin (2.5 or 5 pmol·kg−1·min−1) or a 2-h intragastric infusion of an elemental liquid diet (4 kcal/h). Infusions began just before dark onset. Food intake and meal patterns during the first 4 h of the dark period were determined from continuous computer recordings of changes in food bowl weight. Amylin inhibited food intake by ∼50%, and AC187 attenuated this response by ∼50%. AC187 dose-dependently stimulated food intake (maximal increases from 76 to 171%), whether administered alone or with an intragastric infusion of liquid diet. Amylin reduced mean meal size and meal frequency, AC187 attenuated these responses, and AC187 administration alone increased mean meal size and meal frequency. These results support the hypothesis that endogenous amylin plays an essential role in reducing meal size and increasing the postmeal interval of satiety.
- Subjects :
- Amyloid
medicine.medical_specialty
Food intake
Receptors, Peptide
Physiology
medicine.drug_class
Central nervous system
Amylin
Anorexia
Rats, Sprague-Dawley
Eating
Enteral Nutrition
Physiology (medical)
Internal medicine
medicine
Animals
Intubation, Gastrointestinal
Food, Formulated
Chemistry
digestive, oral, and skin physiology
Antagonist
Receptor antagonist
Peptide Fragments
Receptors, Islet Amyloid Polypeptide
Islet Amyloid Polypeptide
Rats
Endocrinology
medicine.anatomical_structure
Injections, Intravenous
medicine.symptom
Peptides
Hormone
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 287
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....2eb5d653841ea68388ca12016cd7abda