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Echocardiographic and hemodynamic assessment for predicting early clinical events in severe acute mitral regurgitation
Echocardiographic and hemodynamic assessment for predicting early clinical events in severe acute mitral regurgitation
- Source :
- The International Journal of Cardiovascular Imaging. 34:171-175
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The diagnostic role of echocardiographic and hemodynamic assessment in acute mitral regurgitation (AMR) remains unclear. The central question of this study was to determine if echocardiographic and hemodynamic parameters can predict early clinical events in AMR. AMR was induced by percutaneously severing the mitral valve chordae tendineae in 39 Yorkshire pigs. Immediately after AMR induction, echocardiographic and hemodynamic exams were performed, and compared between those who died and those who survived within 30-days of the procedure. Echocardiographic indices of MR severity as well as the left atrial pressure showed significant differences between survivors and non-survivors in univariate analysis. Multi-variate logistic regression analysis revealed that echocardiography-derived regurgitant fraction and vena contracta as well as mean left atrial pressure could be used to segment the cohort into survivors and non-survivors. Our study demonstrated, for the first time, that echocardiographic and hemodynamic assessment of AMR provides predictive information on early clinical events in a clinically relevant animal model of AMR.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Sus scrofa
Hemodynamics
030204 cardiovascular system & hematology
Severity of Illness Index
Article
Ventricular Function, Left
03 medical and health sciences
Atrial Pressure
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Mitral valve
Odds Ratio
Animals
Medicine
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Cardiac imaging
Univariate analysis
Vena contracta
business.industry
Mitral Valve Insufficiency
Stroke Volume
Prognosis
Echocardiography, Doppler, Color
Disease Models, Animal
Logistic Models
medicine.anatomical_structure
Acute Disease
Multivariate Analysis
Regurgitant fraction
Cohort
Disease Progression
Cardiology
Mitral Valve
Atrial Function, Left
Female
Chordae tendineae
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15730743 and 15695794
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- The International Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....2eba12e300cf0fd98578ddb5ab541e85
- Full Text :
- https://doi.org/10.1007/s10554-017-1215-y