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Clinicopathologic Spectrum of Secondary Solid Tumors of the Prostate of Nonurothelial Origin

Authors :
Andres M. Acosta
Jennifer B. Gordetsky
Katrina Collins
Adeboye O. Osunkoya
Ankur R. Sangoi
Hiroshi Miyamoto
Chia-Sui Kao
Kiril Trpkov
Geert J.L.H. Van Leenders
Sara E. Wobker
Fiona Maclean
Priti Lal
Reba E. Daniel
Fadi Brimo
Matthew Wasco
Michelle S. Hirsch
Nicholas Baniak
Julio A. Diaz-Perez
Kristine M. Cornejo
Bonnie Choy
Rohit Mehra
Sean R. Williamson
Jonathan I. Epstein
Andres Matoso
Pathology
Source :
American Journal of Surgical Pathology, 46(9), 1269-1276. Lippincott Williams & Wilkins
Publication Year :
2022
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2022.

Abstract

Secondary involvement of the prostate by urothelial or hematolymphoid neoplasms is relatively common and well-described. In contrast, less is known about the clinicopathologic spectrum of secondary solid tumors of the prostate of nonurothelial origin. This study evaluated a series of secondary nonurothelial solid tumors of the prostate diagnosed at 21 institutions. Eighty-five patients with a median age at diagnosis of 64 years were included. Sixty-two patients had clinically manifest disease (62/85, 73%), 10 were diagnosed incidentally (10/85, 12%), and 13 (13/85, 15%) had no detailed clinical data available about symptomatology at presentation. Among patients with clinically manifest disease, the most common symptoms and signs were lower urinary tract symptoms (either obstructive of irritative; 36/62, 58%), abdominal or pelvic pain or discomfort (16/62, 26%), and hematuria (12/62, 19%). Metastasis and direct invasion occurred at roughly similar frequencies (47% vs. 42%) in this series, and in 11% of the cases, the mechanism of spread to the prostate was unclear/uncertain. Overall, among tumors with confirmed sites of origin, the most common primary sites were gastrointestinal tract (53/85, 62%), lung (9/85, 11%), skin (6/85, 7%), and testis (4/85, 5%). Among metastases, the most common tumor types were lung carcinomas (9/40, 23%), colorectal adenocarcinomas (7/40, 18%), melanoma (6/40, 15%), and germ cell tumors (6/40, 15%). This study demonstrated that secondary involvement of the prostate by solid tumors of nonurothelial origin is commonly symptomatic and that the most frequent sites of origin are the gastrointestinal tract, lung, skin, and testis. These findings are worth considering when lesions with unusual cytomorphology and/or architecture are encountered in prostate specimens.

Details

ISSN :
01475185
Volume :
46
Database :
OpenAIRE
Journal :
American Journal of Surgical Pathology
Accession number :
edsair.doi.dedup.....2ec38af105e63267a7975b8ac05ebe36
Full Text :
https://doi.org/10.1097/pas.0000000000001907