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Modeling Murine Gastric Metaplasia Through Tamoxifen-Induced Acute Parietal Cell Loss
- Source :
- Methods in Molecular Biology ISBN: 9781493936014
- Publication Year :
- 2016
-
Abstract
- Parietal cell loss represents the initial step in the sequential progression toward gastric adenocarcinoma. In the setting of chronic inflammation, the expansion of the mucosal response to parietal cell loss characterizes a crucial transition en route to gastric dysplasia. Here, we detail methods for using the selective estrogen receptor modulator tamoxifen as a novel tool to rapidly and reversibly induce parietal cell loss in mice in order to study the mechanisms that underlie these pre-neoplastic events.
- Subjects :
- 0301 basic medicine
Gastric Metaplasia
Inflammation
Article
Injections
03 medical and health sciences
Mice
Parietal Cells, Gastric
Stomach Neoplasms
Metaplasia
medicine
Animals
Parietal cell
Transition (genetics)
business.industry
Gastric Dysplasia
Disease Models, Animal
Tamoxifen
030104 developmental biology
medicine.anatomical_structure
Selective estrogen receptor modulator
Cancer research
medicine.symptom
business
Precancerous Conditions
medicine.drug
Subjects
Details
- ISBN :
- 978-1-4939-3601-4
- ISSN :
- 19406029
- ISBNs :
- 9781493936014
- Volume :
- 1422
- Database :
- OpenAIRE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Accession number :
- edsair.doi.dedup.....2ec5c789c91be955852dacee593bf72b