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Bariatric surgery in severely obese adolescents improves major comorbidities including hyperuricemia
- Source :
- Metabolism. 63:242-249
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Objective Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight following laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y-gastric bypass (RYGB) in severely obese adolescents. Materials/Methods 10 severely obese adolescents underwent either LSG (n = 5) or RYGB (n = 5). 17 normal weight, healthy, age- and gender-matched adolescents served as a normal weight peer group (NWPG). Pre- and 12 months postoperatively, sUA and relevant metabolic parameters (glucose homeostasis, transaminases, lipids) were compared. Results Preoperatively, sUA was significantly elevated in patients with severe obesity compared to NWPG. Twelve months after LSG and RYGB, a significant decrease in sUA, BMI, CVD risk factors, hepatic transaminases, and HOMA-IR was observed. Reduction in SDS-BMI significantly correlated with changes in sUA. Conclusions sUA levels and metabolic comorbidities improved following bariatric surgery in severely obese adolescents. The impact of changes in sUA on long-term clinical complications of childhood obesity deserves further study.
- Subjects :
- Male
Pediatric Obesity
medicine.medical_specialty
Adolescent
Gastroplasty
Endocrinology, Diabetes and Metabolism
Gastric Bypass
Bariatric Surgery
Pilot Projects
Comorbidity
Hyperuricemia
Childhood obesity
Young Adult
chemistry.chemical_compound
Endocrinology
Internal medicine
Weight Loss
Humans
Medicine
Glucose homeostasis
Endothelial dysfunction
Child
Laparoscopic sleeve gastrectomy
business.industry
nutritional and metabolic diseases
medicine.disease
Obesity, Morbid
Uric Acid
Surgery
Blood pressure
chemistry
Case-Control Studies
Uric acid
Female
Laparoscopy
business
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 00260495
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Metabolism
- Accession number :
- edsair.doi.dedup.....2ecb6a7c8ea2c1a6414414aebd7f3371