Back to Search Start Over

Acquired tick resistance: The trail is hot

Authors :
Melody DeBlasio
Andaleeb Sajid
Geoffrey E. Lynn
Sukanya Narasimhan
Jaqueline Matias
Cheyne Kurokawa
Erol Fikrig
Utpal Pal
Source :
Parasite Immunol
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

Acquired tick resistance is a phenomenon wherein the host elicits an immune response against tick salivary components upon repeated tick infestations. The immune responses, potentially directed against critical salivary components, thwart tick feeding, and the animal becomes resistant to subsequent tick infestations. The development of tick resistance is frequently observed when ticks feed on non-natural hosts, but not on natural hosts. The molecular mechanisms that lead to the development of tick resistance are not fully understood, and both host and tick factors are invoked in this phenomenon. Advances in molecular tools to address the host and the tick are beginning to reveal new insights into this phenomenon and to uncover a deeper understanding of the fundamental biology of tick-host interactions. This review will focus on the expanding understanding of acquired tick resistance and highlight the impact of this understanding on anti-tick vaccine development efforts.

Details

ISSN :
13653024 and 01419838
Volume :
43
Database :
OpenAIRE
Journal :
Parasite Immunology
Accession number :
edsair.doi.dedup.....2ecbf1610a95b1a4143d91f4bea01276
Full Text :
https://doi.org/10.1111/pim.12808