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Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
- Source :
- International Journal of Molecular Sciences, Volume 21, Issue 11, International Journal of Molecular Sciences, Vol 21, Iss 3908, p 3908 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE), for preparedness against a radiological attack or accident. Combined injuries from concomitant trauma and radiation are likely in these scenarios. Either exacerbation or mitigation of radiation damage by wound trauma has been previously reported in preclinical studies. Female WAG/RijCmcr rats received 13 Gy X-rays, with partial-body shielding of one leg. Within 2 h, irradiated rats and non-irradiated controls were given full-thickness skin wounds with or without lisinopril, started orally 7 days after irradiation. Morbidity, skin wound area, breathing interval and blood urea nitrogen were measured up to 160 days post-irradiation to independently evaluate wound trauma and DEARE. Wounding exacerbated morbidity in irradiated rats between 5 and 14 days post-irradiation (during the ARS phase), and irradiation delayed wound healing. Wounding did not alter delayed morbidities from radiation pneumonitis or nephropathy after 30 days post-irradiation. Lisinopril did not mitigate wound healing, but markedly decreased morbidity during DEARE from 31 through 160 days. The results derived from this unique model of combined injuries suggest different molecular mechanisms of injury and healing of ARS and DEARE after radiation exposure.
- Subjects :
- 0301 basic medicine
Exacerbation
Kaplan-Meier Estimate
Blood Urea Nitrogen
lcsh:Chemistry
0302 clinical medicine
Lisinopril
Medicine
Blood urea nitrogen
lcsh:QH301-705.5
Spectroscopy
integumentary system
Acute Radiation Syndrome
rat model of irradiation
leg-out partial body irradiation (PBI)
General Medicine
Computer Science Applications
Radiation Injuries, Experimental
030220 oncology & carcinogenesis
Anesthesia
Breathing
Female
Whole-Body Irradiation
medicine.drug
combined injury
Catalysis
Article
Nephropathy
Inorganic Chemistry
03 medical and health sciences
mitigation
Radiation Protection
Animals
Physical and Theoretical Chemistry
Radiation Injuries
Molecular Biology
Wound Healing
business.industry
X-Rays
Organic Chemistry
medicine.disease
Rats
Radiation Pneumonitis
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Concomitant
Wounds and Injuries
business
Wound healing
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....2ed2c11040111519856ef73bf1cba646
- Full Text :
- https://doi.org/10.3390/ijms21113908