Study of functional activity of the 1A2 insulator and polyadenylation signal in intron of the yellow gene of Drosophila melanogaster

Genomic regulatory elements that can block theinteraction between enhancers and promoters onlywhen they are inserted between them are called insulators [1]. The most wellstudied insulator, found inthe regulatory region of the retrotransposon MDG4,consists of 12 binding sites for the Su(Hw) protein [2].Earlier, the endogenous insulator (1A2) was found inthe laboratory, which contains two binding sites for theSu(Hw) protein and is located at the 3' end of the