Back to Search
Start Over
Role of the HLA Class II - HCV-Related Disorders
- Publication Year :
- 2007
-
Abstract
- The paper highlights the role of different HLA class II molecules in hepatic and lymphoproliferative HCV-related disorders. HLA molecules have been reviewed, according to an in silico cluster classification, based on the sequence, the biochemical structure of the pockets, and the functional characteristics of the HLA II molecules. Thus, by reducing the complexity of HLA II polymorphism, characteristics that unite different HLA molecules with specific HCV-associated pathologies may be recognized with greater case. Results show that HLA clusters associated with better dlimination of the virus are protective against HCC development, while the same clusters are associated with a higher risk of developing cryoglobulinemic syndrome and the concomitant NHL. These data added further acknowledgements on pathogenetic mechanisms associated with HCV infection. Results also highlight differences of NHL occurring in HCV-positive subjects, with or without a concomitant type II autoimmune cryoglobulinemic syndrome, suggesting that cryoglobulinemic background associated with NHL should be considered in the evaluation of the effectiveness of new therapies in the course of HCV-associated NHLs.
- Subjects :
- Hepatocarcinoma
Lymphoma, B-Cell
Lymphoma
Hepacivirus
Hepatitis C virus
Sequence-based typing
Human leukocyte antigen
Major histocompatibility complex
medicine.disease_cause
HCV-related disorders
MHC allele
General Biochemistry, Genetics and Molecular Biology
Autoimmune Diseases
History and Philosophy of Science
medicine
Humans
SBT
HLA-DRB1
B-cell lymphoproliferation
Cryoglobulinemia
HLA DQB1
HLA DRB1
HLA-DQB1
biology
HLA class II
General Neuroscience
Liver Neoplasms
Histocompatibility Antigens Class II
T-Lymphocytes, Helper-Inducer
biology.organism_classification
medicine.disease
Fibrosis
Hepatitis C
Immunology
biology.protein
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2ee882ce44f587748acc9d62ee8f62b1