One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N'-benzyl-N,N-dimethylureas

Authors :: Amany S. Hegazy
Keith Smith
Gamal A. El-Hiti
Source :: Chemical communications (Cambridge, England). 46(16)
Publication Year :: 2010
Abstract: Lithiation of various N'-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 degrees C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.

Subjects :: Indoles
Molecular Structure
Chemistry
One-pot synthesis
Substitution (logic)
Metals and Alloys
General Chemistry
Lithium
Crystallography, X-Ray
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Cyclization
Electrophile
Materials Chemistry
Ceramics and Composites
Anhydrous
Organic chemistry
Urea

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