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Myocardial expression of fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy

Authors :
Richard Holubkov
Toru Kubota
Imac Investigators
Marc J. Semigran
Warren D. Rosenblum
Maninder Bedi
Arthur M. Feldman
William Dec
Richard Sheppard
Dennis M. McNamara
Charles F. McTiernan
Source :
Journal of the American College of Cardiology. 46(6)
Publication Year :
2005

Abstract

ObjectivesThis study aimed to evaluate the role of gene expression for predicting myocardial recovery in recent-onset cardiomyopathy.BackgroundApoptosis may limit ventricular recovery. We examined the myocardial expression of Fas, Fas ligand (FasL), tumor necrosis factor (TNF)-alpha, and TNF receptor 1 (TNFR1), and myocardial recovery in patients from the multicenter Intervention in Myocarditis and Acute Cardiomyopathy (IMAC) study.MethodsEndomyocardial biopsy samples were obtained in 20 patients with recent-onset (

Details

ISSN :
15583597
Volume :
46
Issue :
6
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi.dedup.....2f1ff5c2783b4914349a94b905137070