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The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: a prospective observational study

Authors :
Phylip Rhodri Williams
M. R. Brown
Sophia N. Stanford
Sharon Storton
Simon J. Davidson
John F. Potter
Matthew Lawrence
Karl Hawkins
Ahmed Sabra
Roger H. K. Morris
Vanessa Evans
Phillip A. Evans
Mushtaq Wani
Lindsay D’Silva
Source :
BMC Neurology
Publisher :
Springer Nature

Abstract

Stroke is the second largest cause of death worldwide. Hypercoagulability is a key feature in ischaemic stroke due to the development of an abnormally dense clot structure but techniques assessing the mechanics and quality of clot microstructure have limited clinical use. We have previously validated a new haemorheological technique using three parameters to reflect clot microstructure (Fractal Dimension (d f )) ex-vivo, real-time clot formation time (T GP ) and blood clot strength (elasticity at the gel point (G’GP)). We aimed to evaluate these novel clotting biomarkers in ischaemic stroke and changes of clot structure following therapeutic intervention. In a prospective cohort study clot microstructure was compared in ischaemic stroke patients and a control group of healthy volunteers. Further assessment took place at 2–4 hours and at 24 hours after therapeutic intervention in the stroke group to assess the effects of thrombolysis and anti-platelet therapy. 75 patients (mean age 72.8 years [SD 13.1]; 47 male, 28 female) with ischaemic stroke were recruited. Of the 75 patients, 32 were thrombolysed with t-PA and 43 were loaded with 300 mg aspirin. The following parameters were significantly different between patients with stroke and the 74 healthy subjects: d f (1.760 ± .053 versus 1.735 ± 0.048, p = 0.003), TGP (208 ± 67 versus 231 ± 75, p = 0.05), G’GP (0.056 ± 0.017 versus 0.045 ± 0.014, p

Details

Language :
English
ISSN :
14712377
Volume :
15
Issue :
1
Database :
OpenAIRE
Journal :
BMC Neurology
Accession number :
edsair.doi.dedup.....2f29c9e23ec5bb331b41e915f01f0230
Full Text :
https://doi.org/10.1186/s12883-015-0289-1