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The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: a prospective observational study
- Source :
- BMC Neurology
- Publisher :
- Springer Nature
-
Abstract
- Stroke is the second largest cause of death worldwide. Hypercoagulability is a key feature in ischaemic stroke due to the development of an abnormally dense clot structure but techniques assessing the mechanics and quality of clot microstructure have limited clinical use. We have previously validated a new haemorheological technique using three parameters to reflect clot microstructure (Fractal Dimension (d f )) ex-vivo, real-time clot formation time (T GP ) and blood clot strength (elasticity at the gel point (G’GP)). We aimed to evaluate these novel clotting biomarkers in ischaemic stroke and changes of clot structure following therapeutic intervention. In a prospective cohort study clot microstructure was compared in ischaemic stroke patients and a control group of healthy volunteers. Further assessment took place at 2–4 hours and at 24 hours after therapeutic intervention in the stroke group to assess the effects of thrombolysis and anti-platelet therapy. 75 patients (mean age 72.8 years [SD 13.1]; 47 male, 28 female) with ischaemic stroke were recruited. Of the 75 patients, 32 were thrombolysed with t-PA and 43 were loaded with 300 mg aspirin. The following parameters were significantly different between patients with stroke and the 74 healthy subjects: d f (1.760 ± .053 versus 1.735 ± 0.048, p = 0.003), TGP (208 ± 67 versus 231 ± 75, p = 0.05), G’GP (0.056 ± 0.017 versus 0.045 ± 0.014, p
- Subjects :
- Male
medicine.medical_specialty
Whole Blood Coagulation Time
medicine.medical_treatment
Clinical Neurology
Fibrinogen
Tissue plasminogen activator
Cohort Studies
Fibrinolytic Agents
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
Ischaemic stroke
Aged
Cause of death
Aged, 80 and over
Aspirin
Clot microstructure
business.industry
Thrombosis
Biomarker
General Medicine
Thrombolysis
Middle Aged
medicine.disease
Elasticity
Surgery
Stroke
Fractals
Case-Control Studies
Tissue Plasminogen Activator
Cardiology
Female
Neurology (clinical)
Fractal dimension
business
Fibrinolytic agent
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14712377
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Neurology
- Accession number :
- edsair.doi.dedup.....2f29c9e23ec5bb331b41e915f01f0230
- Full Text :
- https://doi.org/10.1186/s12883-015-0289-1