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Risk of Left Atrial Enlargement in Obese Patients With Obesity-Induced Hypoventilation Syndrome vs Obstructive Sleep Apnea
- Source :
- Ochsner Journal. 18:136-140
- Publication Year :
- 2018
- Publisher :
- Ochsner Journal, 2018.
-
Abstract
- Background: Obstructive sleep apnea (OSA) is a known risk factor for atrial fibrillation (AF) that is principally driven by left atrial enlargement. The impact of hypoventilation caused by obesity-induced hypoventilation syndrome (OHS) on left atrial diameter has not been examined. We investigated the association between OHS and left atrial diameter in obese patients. Methods: We performed a retrospective review of 210 consecutive medical records of patients diagnosed as obese (body mass index [BMI] >30 kg/m2) and as having OHS and OSA for the period January 2010 through December 2016 at St. Vincent Charity Medical Center in Cleveland, OH. Logistic regression analysis was performed for left atrial diameter ≥4 cm in 2 groups of patients: those with OHS+OSA and those with OSA alone. Results: A total of 104 obese patients with OHS+OSA and 106 obese patients with OSA alone were identified. Statistically significant differences were found in 6 demographic and baseline characteristics: median BMI, median left atrial diameter, history of type 2 diabetes mellitus, history of stroke, history of coronary artery disease, and history of congestive heart failure. The median left atrial diameter for the OHS+OSA and OSA alone groups was 4.45 cm and 4.20 cm, respectively (P = 0.014). Left ventricular ejection fraction Conclusion: The results of this study indicate that OHS may be an independent risk factor for left atrial enlargement and may possibly contribute to AF development irrespective of left ventricular function.
- Subjects :
- Obesity hypoventilation syndrome
medicine.medical_specialty
Ejection fraction
business.industry
Atrial fibrillation
General Medicine
030204 cardiovascular system & hematology
medicine.disease
Hypoventilation
Obstructive sleep apnea
03 medical and health sciences
0302 clinical medicine
Heart failure
Internal medicine
medicine
Left atrial enlargement
Cardiology
030212 general & internal medicine
medicine.symptom
business
Stroke
Original Research
Subjects
Details
- ISSN :
- 15245012
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Ochsner Journal
- Accession number :
- edsair.doi.dedup.....2f2b4b47a4f8dcd5b4a88763f815e51c