Back to Search
Start Over
Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
- Source :
- Sikdar, S, Joehanes, R, Joubert, B R, Xu, C-J, Vives-Usano, M, Rezwan, F I, Felix, J F, Ward, J M, Guan, W, Richmond, R C, Brody, J A, Küpers, L K, Baïz, N, Håberg, S E, Smith, J A, Reese, S E, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, C A, Xu, T, Reynolds, L M, Just, A C, Mandaviya, P R, Ghantous, A, Bennett, B D, Wang, T, The BIOS Consortium, Bakulski, K M, Melen, E, Zhao, S, Jin, J, Herceg, Z, Meurs, J V, Taylor, J A, Baccarelli, A A, Murphy, S K, Liu, Y, Munthe-Kaas, M C, Deary, I J, Nystad, W, Waldenberger, M, Annesi-Maesano, I, Conneely, K, Jaddoe, V W, Arnett, D, Snieder, H, Kardia, S L, Relton, C L, Ong, K K, Ewart, S, Moreno-Macias, H, Romieu, I, Sotoodehnia, N, Fornage, M, Motsinger-Reif, A, Koppelman, G H, Bustamante, M, Levy, D & London, S J 2019, ' Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking ', Epigenomics . https://doi.org/10.2217/epi-2019-0066, Epigenomics, Sikdar, S, Joehanes, R, Joubert, B R, Xu, C-J, Vives-Usano, M, Rezwan, F I, Felix, J F, Ward, J M, Guan, W, Richmond, R C, Brody, J A, Kupers, L K, Baïz, N, Haberg, S E, Smith, J A, Reese, S E, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, C A, Relton, C L & al., E 2019, ' Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking ', Epigenomics, vol. 11, no. 13, pp. 1487-1500 . https://doi.org/10.2217/epi-2019-0066, Epigenomics, 11(13), 1487-1500, Epigenomics 11 (2019) 13, Epigenomics 11, 1487-1500 (2019), Epigenomics, 11(13), 1487-1500. FUTURE MEDICINE LTD, Epigenomics, 11(13), 1487-1500. Future Medicine Ltd.
- Publication Year :
- 2019
-
Abstract
- Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
- Subjects :
- 0301 basic medicine
Adult
Epigenomics
Cancer Research
Nutrition and Disease
Offspring
Physiology
cigarette smoking
Biology
Epigenesis, Genetic
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Pregnancy
Voeding en Ziekte
maternal exposure
Genetics
medicine
Tobacco Smoking
Humans
030212 general & internal medicine
Epigenetics
Prenatal exposure
epigenetics
Infant, Newborn
Cigarette Smoking
Infant
Maternal Exposure
Methylation
DNA Methylation
medicine.disease
infant
3. Good health
030104 developmental biology
In utero
Prenatal Exposure Delayed Effects
DNA methylation
CpG Islands
Female
ICEP
methylation
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17501911
- Database :
- OpenAIRE
- Journal :
- Sikdar, S, Joehanes, R, Joubert, B R, Xu, C-J, Vives-Usano, M, Rezwan, F I, Felix, J F, Ward, J M, Guan, W, Richmond, R C, Brody, J A, Küpers, L K, Baïz, N, Håberg, S E, Smith, J A, Reese, S E, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, C A, Xu, T, Reynolds, L M, Just, A C, Mandaviya, P R, Ghantous, A, Bennett, B D, Wang, T, The BIOS Consortium, Bakulski, K M, Melen, E, Zhao, S, Jin, J, Herceg, Z, Meurs, J V, Taylor, J A, Baccarelli, A A, Murphy, S K, Liu, Y, Munthe-Kaas, M C, Deary, I J, Nystad, W, Waldenberger, M, Annesi-Maesano, I, Conneely, K, Jaddoe, V W, Arnett, D, Snieder, H, Kardia, S L, Relton, C L, Ong, K K, Ewart, S, Moreno-Macias, H, Romieu, I, Sotoodehnia, N, Fornage, M, Motsinger-Reif, A, Koppelman, G H, Bustamante, M, Levy, D & London, S J 2019, ' Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking ', Epigenomics . https://doi.org/10.2217/epi-2019-0066, Epigenomics, Sikdar, S, Joehanes, R, Joubert, B R, Xu, C-J, Vives-Usano, M, Rezwan, F I, Felix, J F, Ward, J M, Guan, W, Richmond, R C, Brody, J A, Kupers, L K, Baïz, N, Haberg, S E, Smith, J A, Reese, S E, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, C A, Relton, C L & al., E 2019, ' Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking ', Epigenomics, vol. 11, no. 13, pp. 1487-1500 . https://doi.org/10.2217/epi-2019-0066, Epigenomics, 11(13), 1487-1500, Epigenomics 11 (2019) 13, Epigenomics 11, 1487-1500 (2019), Epigenomics, 11(13), 1487-1500. FUTURE MEDICINE LTD, Epigenomics, 11(13), 1487-1500. Future Medicine Ltd.
- Accession number :
- edsair.doi.dedup.....2f2e121c3e9e9279973e84277f819d26
- Full Text :
- https://doi.org/10.2217/epi-2019-0066