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Role of serum EBV‐VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population
- Source :
- Cancer Medicine
- Publication Year :
- 2018
- Publisher :
- John Wiley and Sons Inc., 2018.
-
Abstract
- The study aimed to investigate the role of serum EBV‐VCA IgG in assessing gastric cancer (GC) risk and prognosis. A total of 1790 Northern Chinese participants with pathologically confirmed disease underwent EBV‐VCA IgG serologic testing using enzyme‐linked immunosorbent assay (ELISA), including 821 controls, 410 atrophic gastritis (AG) patients, and 559 GC patients. We found that positive EBV‐VCA IgG was significantly associated with GC and its precursor, conferring a 1.55‐ and 1.36‐fold increased risk of GC and AG, respectively (P = 0.001, 95% CI = 1.21‐1.99; P = 0.011, 95% CI = 1.07‐1.72, respectively). The risk effects were more remarkable in younger, female, and Helicobacter pylori‐negative individuals than in older, male, and H. pylori‐positive individuals. EBV‐VCA IgG‐positive subjects had a lower PGI/II ratio than EBV‐VCA IgG‐negative subjects (median 8.0 vs 8.8, P = 0.001), especially those in the H. pylori‐positive (median 6.1 vs 6.8, P = 0.027) and GC subgroups (median 6.4 vs 7.9, P = 0.020). In the intestinal GC subgroup, the survival of EBV‐VCA IgG‐positive patients was worse than that of EBV‐VCA IgG‐negative patients (P = 0.041, HR = 2.45, 95% CI = 1.04‐5.78). Our study suggests that EBV‐VCA IgG seropositivity has potential in predicting the risk of GC and its precursor as well as the prognosis of histologically classified GC.<br />This is an innovative report about the role of serum EBV‐VCA IgG detection in assessing the risk of gastric cancer (GC) and its precursor as well as GC prognosis. And this is the first report about the relationship between EBV‐VCA IgG serology assay and gastric function status. Our study provides theoretical and experimental basis for evaluating the potential of serum EBV‐VCA IgG as a biomarker in prediction of GC risk and prognosis.
- Subjects :
- Male
Cancer Research
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Atrophic gastritis
Disease
Gastroenterology
Serology
0302 clinical medicine
Helicobacter
Antigens, Viral
Original Research
risk
Aged, 80 and over
biology
gastric function
Middle Aged
Prognosis
Oncology
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
Cancer Prevention
Adult
medicine.medical_specialty
China
Adolescent
serum EBV
Risk Assessment
03 medical and health sciences
Young Adult
Stomach Neoplasms
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Aged
Chinese population
Helicobacter pylori
business.industry
gastric cancer
Cancer
medicine.disease
biology.organism_classification
Survival Analysis
stomatognathic diseases
Immunoglobulin G
Capsid Proteins
business
Cancer risk
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 7
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....2f3acea947c34c3eea590290dd8b6f47