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The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)

Authors :
Kelsey Gasior
Nikki J. Wagner
Alyson G. Wilson
Marlene L. Hauck
Jhon Cores
Rose Caspar
Sudin Bhattacharya
Source :
Cell Adhesion & Migration, Vol 13, Iss 1, Pp 63-75 (2019), Cell Adhesion & Migration
Publication Year :
2018
Publisher :
Informa UK Limited, 2018.

Abstract

The epithelial mesenchymal transition (EMT) is one step in the process through which carcinoma cells metastasize by gaining the cellular mobility associated with mesenchymal cells. This work examines the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells. While the SW480 population revealed an intermediate state between the epithelial and mesenchymal states, the MC7 cells exhibited highly adhesive behavior. However, for both cell lines, an exogenous TGF-β signal and a reduction in cellular confluence can push a subgroup of the population towards the mesenchymal phenotype. Together, these results highlight that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.

Details

ISSN :
19336926 and 19336918
Volume :
13
Database :
OpenAIRE
Journal :
Cell Adhesion & Migration
Accession number :
edsair.doi.dedup.....2f3c5a98de86d3dde619dc596a2cff1b
Full Text :
https://doi.org/10.1080/19336918.2018.1526597