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The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)
- Source :
- Cell Adhesion & Migration, Vol 13, Iss 1, Pp 63-75 (2019), Cell Adhesion & Migration
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- The epithelial mesenchymal transition (EMT) is one step in the process through which carcinoma cells metastasize by gaining the cellular mobility associated with mesenchymal cells. This work examines the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells. While the SW480 population revealed an intermediate state between the epithelial and mesenchymal states, the MC7 cells exhibited highly adhesive behavior. However, for both cell lines, an exogenous TGF-β signal and a reduction in cellular confluence can push a subgroup of the population towards the mesenchymal phenotype. Together, these results highlight that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.
- Subjects :
- 0301 basic medicine
Cell type
Epithelial-Mesenchymal Transition
emt
Population
Breast Neoplasms
epithelial
colon carcinoma
Adenocarcinoma
mesenchymal
tgf-β
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Cell Movement
Transforming Growth Factor beta
TGF beta signaling pathway
Cell Adhesion
Tumor Cells, Cultured
Humans
breast carcinoma
Epithelial–mesenchymal transition
lcsh:QH573-671
education
Cell adhesion
education.field_of_study
lcsh:Cytology
Chemistry
Mesenchymal stem cell
cellular adhesion
Cell Biology
Cell biology
030104 developmental biology
Cell culture
030220 oncology & carcinogenesis
Female
Colorectal Neoplasms
Signal Transduction
Research Article
Transforming growth factor
Subjects
Details
- ISSN :
- 19336926 and 19336918
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cell Adhesion & Migration
- Accession number :
- edsair.doi.dedup.....2f3c5a98de86d3dde619dc596a2cff1b
- Full Text :
- https://doi.org/10.1080/19336918.2018.1526597