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Novel effects of statins in enhancing efficacy of chemotherapy in vitro in nasopharyngeal carcinoma
- Source :
- International forum of allergyrhinology. 1(4)
- Publication Year :
- 2010
-
Abstract
- Background Nasopharyngeal cancer (NPC) is a relatively uncommon malignant epithelial cancer seen worldwide. The treatment of NPC has evolved toward combined modality treatment with radiation therapy and chemotherapy. However, chemotherapeutic agents currently have a secondary role, due to their lack of efficacy as curative agents. Recent identification of a novel property of statin drugs raises a promising hope that concurrent use of statins may enhance the efficacy of single-drug chemotherapy in NPC. However, the effects of statins have not been studied before in NPC. In this in vitro study, we demonstrate a unique property of statins that can enhance the efficacy of cisplatin in NPC. Methods Primary human NPC cells (CCL-30) were treated with statins and cisplatin concurrently, and the effects on cell proliferation, apoptosis, and cell colony formation were examined. Results Statins caused significant decrease in cell proliferation and viability in NPC. Statins also induced loss of cell attachment, change in cellular morphology, decrease in colony forming units, and loss of sphere formation in soft gel agar, which are the important properties of tumorigenicity in NPC. Furthermore, we found that the effects of statins occur by a mevalonate (MA)-mediated pathway in these cells. Conclusions We demonstrate a unique property of statins that can enhance the antitumor effects of cisplatin in NPC. Statins may act as a relatively safe and cost effective chemoadjuvant agent in the treatment of NPC. © 2011 ARS-AAOA, LLC.
- Subjects :
- Statin
medicine.drug_class
Cell Survival
medicine.medical_treatment
Cell
Mevalonic Acid
Antineoplastic Agents
Pharmacology
otorhinolaryngologic diseases
medicine
Tumor Cells, Cultured
Immunology and Allergy
Humans
Cisplatin
Chemotherapy
Nasopharyngeal Carcinoma
Cell growth
business.industry
Caspase 3
Carcinoma
Drug Synergism
Nasopharyngeal Neoplasms
medicine.disease
Radiation therapy
stomatognathic diseases
medicine.anatomical_structure
Otorhinolaryngology
Nasopharyngeal carcinoma
Apoptosis
Cancer research
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
medicine.drug
Signal Transduction
Subjects
Details
- ISSN :
- 20426984
- Volume :
- 1
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- International forum of allergyrhinology
- Accession number :
- edsair.doi.dedup.....2f5d6dc18d6ecbc69655f1812e61c7ce