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Effect of betamethasone, indomethacin and fenoterol on neonatal and maternal mononuclear cells stimulated with Escherichia coli
- Source :
- Cytokine. 116:97-105
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Despite considerable progress in the field of perinatal care, infectious diseases, especially when caused by gram negative bacteria, remain a major reason for neonatal morbidity and mortality. Notably infants born prematurely and those with very low birth weight are at risk due to their immature and deficient immune system and their prolonged hospitalization which promotes nosocomial infections. In case of impending preterm birth, betamethasone is given to induce lung maturation and tocolytic agents like indomethacin or fenoterol are administered to suppress premature labor. The aim of this study was to analyze the effects of these drugs on the immune system of mothers and neonates. Therefore, mononuclear cells from cord blood and peripheral maternal blood were stimulated with Escherichia coli and incubated with betamethasone, indomethacin and fenoterol. Subsequently the effect of the treatment on cytokine production was determined. Betamethasone alone and in combination with tocolytic agents inhibited the production of pro- and anti-inflammatory cytokines. Not only does betamethasone dampen the immune response by reducing the production of cytokines, it also has a variety of other detrimental short- and long-term effects on the neonate. In conclusion we would recommend using biological markers to determine if premature labor actually leads to preterm birth and subsequently administer betamethasone only to mothers giving birth prematurely.
- Subjects :
- Adult
0301 basic medicine
Tocolytic agent
medicine.medical_treatment
Indomethacin
Immunology
Anti-Inflammatory Agents
Physiology
Betamethasone
Biochemistry
Young Adult
03 medical and health sciences
Obstetric Labor, Premature
0302 clinical medicine
Immune system
Pregnancy
Escherichia coli
medicine
Humans
Immunology and Allergy
Molecular Biology
Fenoterol
Neonatal sepsis
business.industry
Infant, Newborn
Hematology
medicine.disease
Low birth weight
Tocolytic Agents
030104 developmental biology
Cytokine
030220 oncology & carcinogenesis
Cord blood
Leukocytes, Mononuclear
Cytokines
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 10434666
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- Cytokine
- Accession number :
- edsair.doi.dedup.....2f68e85bc07b1426b9085fd6b4f9d215