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Association of endometriosis and breast cancer: mini review of the literature
- Source :
- Archives of Gynecology and Obstetrics. 293:5-10
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Endometriosis is a common, estrogen-dependent, gynecological disease, which is defined as the presence of endometrial tissue outside the uterine cavity. Current data have associated endometriosis with specific malignancies, including ovarian and breast cancer.The purpose of our study is to summarize and present published literature providing evidence regarding the possible relationship between endometriosis and breast cancer.Pubmed and Scopus databases were searched systematically for studies that sought to identify a potential association of endometriosis and breast cancer. 15 relevant articles were retrieved and included in the present review.A small number of observational studies have shown a correlation of endometriosis and breast cancer. Other studies found that the risk of breast cancer increases with age. The scenario of an early interruption of the inflammatory process, derived from endometriosis, by oophorectomy and a possible consequent decrease in the risk of breast cancer has also been proposed. The hypothesis that both conditions could be related through common mutations on BRAC1 and BRAC2 genes has also been investigated.The available published evidence is inconclusive. Further studies are needed to evaluate the association of endometriosis and breast cancer and the possible pathogenetic pathways that relate the two disorders.
- Subjects :
- Risk
Oncology
medicine.medical_specialty
Gynecological disease
Endometriosis
Breast Neoplasms
Endometrial tissue
Mini review
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Humans
Medicine
Gynecology
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
Estrogens
General Medicine
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Uterine cavity
business
Genital Diseases, Female
Subjects
Details
- ISSN :
- 14320711 and 09320067
- Volume :
- 293
- Database :
- OpenAIRE
- Journal :
- Archives of Gynecology and Obstetrics
- Accession number :
- edsair.doi.dedup.....2f6f07194eb1130d07940c602ab95c1e