Back to Search
Start Over
Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis
- Source :
- BMC Neuroscience, Vol 21, Iss 1, Pp 1-11 (2020), BMC Neuroscience
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the functional connectivity of resting-state brain networks (RSNs) among adolescent patients with different subtypes of ADHD. Methods The data were obtained from the ADHD-200 Global Competition, including fMRI data from 88 ADHD patients (56 patients of ADHD-Combined, ADHD-C and 32 patients of ADHD-Inattentive, ADHD-I) and 67 typically developing controls (TD-C). Group ICA was utilized to research aberrant brain functional connectivity within the different subtypes of ADHD. Results In comparison with the TD-C group, the ADHD-C group showed clusters of decreased functional connectivity in the left inferior occipital gyrus (p = 0.0041) and right superior occipital gyrus (p = 0.0011) of the dorsal attention network (DAN), supplementary motor area (p = 0.0036) of the executive control network (ECN), left supramarginal gyrus (p = 0.0081) of the salience network (SN), middle temporal gyrus (p = 0.0041), and superior medial frontal gyrus (p = 0.0055) of the default mode network (DMN), while the ADHD-I group showed decreased functional connectivity in the right superior parietal gyrus (p = 0.0017) of the DAN and left middle temporal gyrus (p = 0.0105) of the DMN. In comparison with the ADHD-I group, the ADHD-C group showed decreased functional connectivity in the superior temporal gyrus (p = 0.0062) of the AN, inferior temporal gyrus (p = 0.0016) of the DAN, and the dorsolateral superior frontal gyrus (p = 0.0082) of the DMN. All the clusters surviving at p Conclusion The results suggested that decreased functional connectivity within the DMN and DAN was responsible, at least in part, for the symptom of inattention in ADHD-I patients. Similarly, we believed that the impaired functional connectivity within networks may contribute to the manifestations of ADHD-C patients, including inattention, hyperactivity/impulsivity, and unconscious movements.
- Subjects :
- Male
Middle temporal gyrus
Audiology
Executive Function
Superior temporal gyrus
Functional connectivity
0302 clinical medicine
Parietal Lobe
Neural Pathways
Medicine
Attention
Child
Default mode network
Cerebral Cortex
Principal Component Analysis
General Neuroscience
05 social sciences
fMRI
lcsh:QP351-495
Magnetic Resonance Imaging
Temporal Lobe
medicine.anatomical_structure
Female
Research Article
medicine.medical_specialty
Adolescent
Rest
behavioral disciplines and activities
050105 experimental psychology
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
Inferior temporal gyrus
Task-positive network
mental disorders
RSNs
Humans
ADHD
0501 psychology and cognitive sciences
ICA
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Resting state fMRI
business.industry
Default Mode Network
Medial frontal gyrus
lcsh:Neurophysiology and neuropsychology
Superior frontal gyrus
Attention Deficit Disorder with Hyperactivity
Nerve Net
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14712202
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Neuroscience
- Accession number :
- edsair.doi.dedup.....2f86c9c4daac81988c533499e6f5ace7