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Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines
- Source :
- Bioorganic & Medicinal Chemistry. 20:3287-3291
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- An artificial antigen forming the C34 trimeric structure targeting membrane-fusion mechanism of HIV-1 has been evaluated as an HIV vaccine. The C34 trimeric molecule was previously designed and synthesized using a novel template with C3-symmetric linkers by us. The antiserum produced by immunization of the C34 trimeric form antigen showed 23-fold higher binding affinity for the C34 trimer than for the C34 monomer and showed significant neutralizing activity. The present results suggest effective strategies of the design of HIV vaccines and anti-HIV agents based on the native structure mimic of proteins targeting dynamic supramolecular mechanisms in HIV fusion.
- Subjects :
- Male
Anti-HIV Agents
HIV Antigens
Molecular Sequence Data
Clinical Biochemistry
Pharmaceutical Science
Enzyme-Linked Immunosorbent Assay
Trimer
HIV Antibodies
Gp41
Biochemistry
Cell Line
Mice
chemistry.chemical_compound
Antigen
Neutralization Tests
Drug Discovery
Animals
Humans
Amino Acid Sequence
HIV vaccine
Molecular Biology
Cells, Cultured
AIDS Vaccines
Antiserum
Mice, Inbred BALB C
Organic Chemistry
Virology
HIV Envelope Protein gp41
Peptide Fragments
Monomer
Immunization
chemistry
Molecular Medicine
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....2f889c10246dc58249cfe427c409f35b
- Full Text :
- https://doi.org/10.1016/j.bmc.2012.03.050