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Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines

Authors :
Aki Ohya
Hirokazu Tamamura
Tetsuo Narumi
Kosuke Miyauchi
Jun Komano
Wataru Nomura
Chie Hashimoto
Naoki Yamamoto
Haruo Aikawa
Emiko Urano
Source :
Bioorganic & Medicinal Chemistry. 20:3287-3291
Publication Year :
2012
Publisher :
Elsevier BV, 2012.

Abstract

An artificial antigen forming the C34 trimeric structure targeting membrane-fusion mechanism of HIV-1 has been evaluated as an HIV vaccine. The C34 trimeric molecule was previously designed and synthesized using a novel template with C3-symmetric linkers by us. The antiserum produced by immunization of the C34 trimeric form antigen showed 23-fold higher binding affinity for the C34 trimer than for the C34 monomer and showed significant neutralizing activity. The present results suggest effective strategies of the design of HIV vaccines and anti-HIV agents based on the native structure mimic of proteins targeting dynamic supramolecular mechanisms in HIV fusion.

Details

ISSN :
09680896
Volume :
20
Database :
OpenAIRE
Journal :
Bioorganic & Medicinal Chemistry
Accession number :
edsair.doi.dedup.....2f889c10246dc58249cfe427c409f35b
Full Text :
https://doi.org/10.1016/j.bmc.2012.03.050