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Thyroid disrupting chemicals
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 18, Iss 12, p 2583 (2017)
- Publication Year :
- 2017
-
Abstract
- Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. Thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority. In this review we examined the most recent studies, many of them concentrating on maternal and child exposure, conducted to assess the impact of industrial chemicals which showed an impact on thyroid function. So far, the number of studies conducted on that topic is not sufficient to provide solid conclusions and lead to homogeneous guidelines. The lack of uniformity is certainly due to differences in areas and populations examined, the different conditions of exposures and the remarkable inter-subject variability. Nonetheless, the European Commission for Health and Food Safety is implementing recommendations to ensure that substances identified as endocrine disruptors will be withdrawn from the market.
- Subjects :
- 0301 basic medicine
Male
Thyroid Gland
Review
010501 environmental sciences
Endocrine Disruptors
01 natural sciences
lcsh:Chemistry
Medicine
Disrupting compound
lcsh:QH301-705.5
Spectroscopy
Thyroid
biology
Computer Science Applications1707 Computer Vision and Pattern Recognition
General Medicine
Environmental exposure
Computer Science Applications
medicine.anatomical_structure
Endocrine disruptor
Maternal Exposure
Female
Thyroid function
medicine.medical_specialty
Thyroid Hormones
endocrine system
Catalysis
Thyroid hormone receptor beta
Inorganic Chemistry
03 medical and health sciences
general_medical_research
Thyroid peroxidase
Thyroid-stimulating hormone (TSH)
Internal medicine
Environmental health
Humans
Endocrine system
Cognitive skill
Physical and Theoretical Chemistry
Molecular Biology
0105 earth and related environmental sciences
business.industry
Hypothalamus pituitary thyroid axis
Organic Chemistry
Environmental Exposure
Food safety
Thyroid hormone
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
Action (philosophy)
biology.protein
business
Hormone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 18, Iss 12, p 2583 (2017)
- Accession number :
- edsair.doi.dedup.....2fa16b438fb73973d7dc4c3e5355af1b