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The application of image analysis and neural network technology to the study of large-cell liver-cell dysplasia and hepatocellular carcinoma
- Source :
- Hepatology. 26:1224-1231
- Publication Year :
- 1997
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1997.
-
Abstract
- Liver cell dysplasia (LCD) is considered a preneoplastic lesion, whose characterization and differentiation from hepatocellular carcinoma (HCC) and from the reactive changes seen in cirrhosis has been controversial. We studied 12 cases of LCD (large cell type) with image analysis techniques (IA) and compared the findings with those of HCC (n = 40), and a spectrum of non-neoplastic hepatic lesions including normal liver and cirrhosis (n = 49). A minimum of 200 Feulgen-stained nuclei were measured from each lesion with the CAS 200 image analysis system. The data were collected with the aid of CellSheet software. Thirty-four variables were measured, including geometric, textural, and photometric nuclear features and DNA ploidy. The data were analyzed with multivariate statistics and a backpropagation neural network (NN). Stepwise statistical analysis selected 22 variables that were statistically significant in the three groups with P values
- Subjects :
- Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Cirrhosis
Diagnosis, Differential
Lesion
Text mining
Image Processing, Computer-Assisted
medicine
Carcinoma
Humans
Cell Nucleus
Ploidies
Hepatology
business.industry
Large cell
Liver cell
Liver Neoplasms
DNA, Neoplasm
medicine.disease
Liver
Dysplasia
Hepatocellular carcinoma
Neural Networks, Computer
medicine.symptom
business
Precancerous Conditions
Subjects
Details
- ISSN :
- 15273350 and 02709139
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Hepatology
- Accession number :
- edsair.doi.dedup.....2fb8780b92636d3bc6947761fca2b934
- Full Text :
- https://doi.org/10.1002/hep.510260521