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Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort
- Source :
- Malaria Journal, Malaria Journal, 2019, 18, pp.194. ⟨10.1186/s12936-019-2831-x⟩, Adamou, R, Dechavanne, C, Sadissou, I, d'Almeida, T, Bouraima, A, Sonon, P, Amoussa, R, Cottrell, G, Le Port, A, Theisen, M, Remarque, E J, Longacre, S, Moutairou, K, Massougbodji, A, Luty, A J F, Nuel, G, Migot-Nabias, F, Sanni, A, Garcia, A, Milet, J & Courtin, D 2019, ' Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort ', Malaria Journal, vol. 18, 194 . https://doi.org/10.1186/s12936-019-2831-x, Malaria Journal, BioMed Central, 2019, 18, pp.194. ⟨10.1186/s12936-019-2831-x⟩, Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND: Substantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from malaria. The specific targets mediating immunity remain unclear. Evaluating antibody responses in infants naturally-exposed to malaria will allow to better understand the establishment of anti-malarial immunity and to contribute to a vaccine development by identifying the most appropriate merozoite candidate antigens.METHODS: The study was based on parasitological and clinical active follow-up of infants from birth to 18 months of age conducted in the Tori Bossito area of southern Benin. For 399 infants, plasma levels of cytophilic IgG antibodies with specificity for five asexual stage malaria vaccine candidate antigens were determined by ELISA in infants' peripheral blood at 6, 9, 12 and 15 months of age. Multivariate mixed logistic model was used to investigate the association between antibody levels and anti-malarial protection in the trimester following the IgG quantification. Moreover, the concentrations of merozoite antigen-specific IgG were compared between a group of infants apparently able to control asymptomatic malaria infection (CAIG) and a group of infants with no control of malaria infection (Control group (NCIG)). Protective effect of antibodies was also assessed after 15 months of malaria exposure with a Cox regression model adjusted on environmental risk.RESULTS: Cytophilic IgG responses to AMA1, MSP1, MSP2-3D7, MSP2-FC27, MSP3 and GLURP R2 were associated with increasing malarial infection risk in univariate analysis. The multivariate mixed model showed that IgG1 and IgG3 to AMA1 were associated with an increased risk of malarial infection. However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183). The latter IgG responses were not associated with protection against clinical malaria in the whole cohort when protective effect is assessed after 15 months of malaria exposition.CONCLUSION: In this cohort, merozoite antigen-specific cytophilic IgG levels represent a marker of malaria exposure in infants from 6 to 18 months of age. However, infants with resolution of asymptomatic infection (CAIG) seem to have acquired naturally immunity against P. falciparum. This observation is encouraging in the context of the development of multitarget P. falciparum vaccines.
- Subjects :
- Male
Protozoan Proteins
Antibodies, Protozoan
MESH: Malaria, Falciparum/immunology
0302 clinical medicine
MESH: Pregnancy
MESH: Antigens, Protozoan/immunology
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Pregnancy
Surveys and Questionnaires
Benin
030212 general & internal medicine
MESH: Plasmodium falciparum/immunology
Longitudinal Studies
Malaria, Falciparum
MESH: Longitudinal Studies
MESH: Antibodies, Protozoan/blood
biology
Malaria vaccine
MESH: Infant, Newborn
MESH: Enzyme-Linked Immunosorbent Assay
MESH: Infant
3. Good health
Infectious Diseases
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
Cytophilic IgG
Female
Merozoite vaccine candidate antigens
Antibody
medicine.symptom
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
030231 tropical medicine
Plasmodium falciparum
Context (language use)
Antigens, Protozoan
Enzyme-Linked Immunosorbent Assay
Asymptomatic
lcsh:Infectious and parasitic diseases
03 medical and health sciences
MESH: Benin
Antigen
Immunity
parasitic diseases
medicine
Humans
lcsh:RC109-216
MESH: Surveys and Questionnaires
MESH: Humans
business.industry
Research
Infant, Newborn
Infant
biology.organism_classification
medicine.disease
MESH: Protozoan Proteins/immunology
MESH: Male
Malaria
Immunoglobulin G
Immunology
biology.protein
Parasitology
business
MESH: Immunoglobulin G/blood
MESH: Female
Subjects
Details
- ISSN :
- 14752875
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Malaria journal
- Accession number :
- edsair.doi.dedup.....2fc19e3ed3851c579e678734f53d6616