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Association Between MIF-AS rs755622 and Nephrolithiasis Risk in a Chinese Population
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2016
-
Abstract
- BACKGROUND Single-nucleotide polymorphisms (SNPs) located at lncRNA may affect the stability and splicing processes of mRNA formation, which result in the alteration of its interacting partners. The SNP rs755622 within exon of antisense lncRNA MIF- AS and promoter of MIF was implicated in renal disease risk. MATERIAL AND METHODS In this case-control study, we genotyped the SNP rs755622 in 230 patients diagnosed with nephrolithiasis and 250 controls in a Chinese population. RESULTS We found that the rs755622 CG and CC genotypes had a significantly increased nephrolithiasis risk (adjusted OR=1.52, 95% CI=1.03-2.25; OR=2.63, 95% CI=1.21-5.72, P=0.015), compared with GG genotype in the additive model. The rs755622 C carriers (GC/CC) had an adjusted OR (95% CI) of 1.65 (1.14-2.39, P=0.016), compared with the GG genotype in the dominant model. This hazardous effect was more pronounced in subgroup age >46, BMI >24, hypertension, ever smoking, and ever drinking subjects. Moreover, we found that rs755622 could modulate the function of MIF-AS by influencing its folding. CONCLUSIONS These results indicate that the MIF-AS rs755622 polymorphism may have a crucial role in the development of nephrolithiasis.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Single-nucleotide polymorphism
Biology
Bioinformatics
Nephrolithiasis
Polymorphism, Single Nucleotide
03 medical and health sciences
Exon
0302 clinical medicine
Asian People
Gene Frequency
Risk Factors
Clinical Research
Internal medicine
Genotype
medicine
SNP
Humans
Computer Simulation
Genetic Predisposition to Disease
Allele frequency
Genetic Association Studies
Chinese population
Case-control study
General Medicine
Middle Aged
030104 developmental biology
Endocrinology
030220 oncology & carcinogenesis
Case-Control Studies
Nucleic Acid Conformation
Dominant model
Female
RNA, Long Noncoding
Subjects
Details
- ISSN :
- 16433750
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Medical science monitor : international medical journal of experimental and clinical research
- Accession number :
- edsair.doi.dedup.....2fc6a53154742d585da7ad5cff68d3a7