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Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity
- Source :
- Immunity, Chai, Qian; Onder, Lucas; Scandella, Elke; Gil-Cruz, Cristina; Perez-Shibayama, Christian; Cupovic, Jovana; Danuser, Renzo; Sparwasser, Tim; Luther, Sanjiv A.; Thiel, Volker; Rülicke, Thomas; Stein, Jens Volker; Hehlgans, Thomas; Ludewig, Burkhard (2013). Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity, 38(5), pp. 1013-1024. Cell Press 10.1016/j.immuni.2013.03.012
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- SummaryThe stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs. Although T cell zone reticular cells had lost podoplanin expression, they still formed a functional conduit system and showed enhanced expression of myofibroblastic markers. However, essential immune functions of FRCs, including homeostatic chemokine and interleukin-7 expression, were impaired. These changes in T cell zone reticular cell function were associated with increased susceptibility to viral infection. Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LTβR-dependent maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection.
- Subjects :
- Lymphotoxin-beta
Chemokine
Pathology
medicine.medical_specialty
Stromal cell
Cellular differentiation
T-Lymphocytes
Immunology
Mice, Transgenic
610 Medicine & health
03 medical and health sciences
Mice
0302 clinical medicine
Immune system
Reticular cell
Lymphotoxin beta Receptor
medicine
Animals
Immunology and Allergy
Progenitor cell
Myofibroblasts
Lymph node
Cells, Cultured
030304 developmental biology
0303 health sciences
Murine hepatitis virus
Membrane Glycoproteins
biology
Interleukin-7
Mesenchymal stem cell
Cell Differentiation
Mesenchymal Stem Cells
Fibroblasts
3. Good health
Cell biology
Mice, Inbred C57BL
medicine.anatomical_structure
Infectious Diseases
biology.protein
Lymph Nodes
Coronavirus Infections
030215 immunology
Signal Transduction
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 38
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....2fd8058d348f0fd46fc676682e489097
- Full Text :
- https://doi.org/10.1016/j.immuni.2013.03.012