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Association between circulating vascular-related microRNAs and an increase in blood pressure: a 5-year longitudinal population-based study
- Source :
- Journal of hypertension. 39(1)
- Publication Year :
- 2020
-
Abstract
- Objective MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and play essential roles in the pathogenesis of cardiovascular disease. Previous cross-sectional studies showed that the levels of several circulating miRNA are associated with hypertension, but there are no prospective longitudinal studies using a general population. The aim of this study is to evaluate the impact of circulating vascular-related miRNA (miR-126, miR-221, and miR-222) on changes in blood pressure and new-onset hypertension in a Japanese population. Methods We conducted a 5-year longitudinal study using 192 health examination participants (87 men and 105 women). Serum miRNAs were measured using quantitative reverse transcription-PCR. Information regarding lifestyle and health condition was obtained using a self-administered questionnaire. Logistic regression analyses were performed to calculate odds ratios and 95% confidence intervals for new-onset hypertension in the 5-year period between the low and high group of serum miRNAs. Results Serum levels of miR-126, miR-221, and miR-222 were significantly and negatively associated with changes in SBP and the rate of change of SBP. Serum miR-126, miR-221, and miR-222 levels were significantly lower in new-onset hypertensive patients compared with normotensive individuals. The confounding factors adjusted odds ratios of each 1 increment in serum miR-126, miR-221, and miR-222 levels were 0.82 (95% confidence interval: 0.69-0.98), 0.79 (0.68-0.91), and 0.61 (0.46-0.81) for new-onset hypertension, respectively. Conclusion Low serum levels of miR-126, miR-221, and miR-222 were associated with increased blood pressure and new-onset of hypertension. These circulating miRNAs are potential candidate biomarkers for the prediction of hypertension.
- Subjects :
- Male
Longitudinal study
Physiology
Population
Blood Pressure
Disease
030204 cardiovascular system & hematology
Logistic regression
03 medical and health sciences
0302 clinical medicine
Internal Medicine
Medicine
Humans
030212 general & internal medicine
Circulating MicroRNA
Longitudinal Studies
education
education.field_of_study
business.industry
Confounding
Odds ratio
Confidence interval
MicroRNAs
Blood pressure
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 14735598
- Volume :
- 39
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of hypertension
- Accession number :
- edsair.doi.dedup.....2fdf1248fdb7b4ced79908c910ab6557