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Clinicopathologic features of single bone metastasis in breast cancer
- Source :
- Medicine
- Publication Year :
- 2021
- Publisher :
- Lippincott Williams & Wilkins, 2021.
-
Abstract
- The most common site for metastasis in patients with breast cancer is the bone. In this case series, we investigated patients whose surgical and medical treatment for primary breast cancer was conducted at our center and first disease recurrence was limited to only 1 bone. We analyzed 910 breast cancer patients, 863 had no metastasis and 47 cases had a single bone metastasis ≥ 6 months after their first diagnosis. Demographic, epidemiological, histopathological and intrinsic tumor subtype differences between the non-metastatic group and the group with solitary bone metastases and their statistical significance were examined. Among established breast cancer risk factors, we studied twenty-nine variables. Three variables (Type of tumor surgery, TNM Stage III tumors and mixed type (invasive ductalcarsinoma + invasive lobular carcinoma) histology) were significant in multivariate logistic regression analysis. Accordingly, the risk of developing single bone metastasis was approximately 15 times higher in patients who underwent mastectomy and 4.8 and 2.8 times higher in those with TNM Stage III tumors and with mixed type (invasive ductal carcinoma + invasive lobular carcinoma) histology, respectively. In conclusion, the risk of developing single bone metastasis is likely in non-metastatic patients with Stage III tumors and possibly in mixed type tumors. Knowing this risk, especially in patients with mixed type tumors, may be instrumental in taking measures with different adjuvant therapies in future studies. Among these, treatment modalities such as prolonged hormone therapy and addition of bisphosphonates to the adjuvant treatments of stage III and mixed breast cancer patients may be considered.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
medicine.medical_treatment
Observational Study
Bone Neoplasms
Breast Neoplasms
Disease
Bone and Bones
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Medicine
Humans
030212 general & internal medicine
Stage (cooking)
Neoplasm Metastasis
Aged
business.industry
Bone metastasis
General Medicine
Middle Aged
medicine.disease
030220 oncology & carcinogenesis
Invasive lobular carcinoma
isolated bone metastasis
Female
Hormone therapy
business
metastatic disease
Mastectomy
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 100
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....30090aab7084d89a9ed31ebf5c187b51