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Report of an NIAID workshop on dengue animal models
Report of an NIAID workshop on dengue animal models
- Source :
- Vaccine. 28:4229-4234
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Dengue is a mosquito-borne viral disease of humans that has re-emerged in many parts of the world and has become an important international public health threat. Dengue incidence and geographical spread has dramatically increased in the last few decades and is now affecting most tropical and sub-tropical regions of the world. Despite extensive research efforts for several decades, no vaccines or therapeutics are currently available to prevent and treat dengue infections. One of the main obstacles to the development of countermeasures has been the lack of good animal models that recapitulate dengue pathogenesis in humans and reliably predict the safety and efficacy of countermeasures against dengue. In September 2008, the National Institute of Allergy and Infectious Diseases (NIAID) held a workshop to consider the current state-of-the-art developments in animal models for dengue and discuss strategies to accelerate progress in this field. This report summarizes the main discussions and recommendations that resulted from the meeting.
- Subjects :
- Biomedical Research
Pan troglodytes
Swine
Dengue Vaccines
Article
Dengue fever
Dengue
Mice
National Institute of Allergy and Infectious Diseases (U.S.)
Environmental health
medicine
Animals
Humans
Dengue vaccine
General Veterinary
General Immunology and Microbiology
Extramural
business.industry
Public Health, Environmental and Occupational Health
International health
medicine.disease
Macaca mulatta
United States
Infectious Diseases
Models, Animal
Immunology
Swine, Miniature
Molecular Medicine
business
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....300981bd964fb1e5cc43326ea3e912ba
- Full Text :
- https://doi.org/10.1016/j.vaccine.2010.04.045