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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans
- Source :
- Genes & Development. 32:1562-1575
- Publication Year :
- 2018
- Publisher :
- Cold Spring Harbor Laboratory, 2018.
-
Abstract
- Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.
- Subjects :
- Transcriptional Activation
0301 basic medicine
endocrine system
media_common.quotation_subject
Longevity
03 medical and health sciences
Subcutaneous Tissue
0302 clinical medicine
Heat shock protein
Genetics
Daf-16
Animals
Insulin
Insulin-Like Growth Factor I
Caenorhabditis elegans
Caenorhabditis elegans Proteins
HSF1
Transcription factor
media_common
biology
Forkhead Transcription Factors
Prefoldin
Cell biology
Intestines
030104 developmental biology
Chaperone (protein)
biology.protein
Chaperone complex
030217 neurology & neurosurgery
Research Paper
Molecular Chaperones
Protein Binding
Signal Transduction
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 15495477 and 08909369
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Genes & Development
- Accession number :
- edsair.doi.dedup.....300f1a13bc5b3dded79e55dd1c3ae81a