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Characterization of intragastric pressure waveform in endoscopic pressure study integrated system: Novel diagnostic device for gastroesophageal reflux disease
- Source :
- Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy SocietyReferences. 33(5)
- Publication Year :
- 2020
-
Abstract
- OBJECTIVES Endoscopic pressure study integrated system (EPSIS) is a novel diagnostic tool for gastroesophageal reflux disease (GERD). EPSIS has been developed to evaluate lower esophageal sphincter function by monitoring the intragastric pressure (IGP) while insufflating the stomach during gastroscopy. Based on previous data, EPSIS could diagnose GERD with good accuracy by assessing IGP waveform pattern. This study aimed to further characterize the waveform to improve the diagnostic yield of EPSIS. METHODS We conducted a retrospective analysis of patients with typical GERD symptoms who underwent both EPSIS and 24-h impedance-pH monitoring (MII-pH) at a single tertiary referral center from October 2018 to May 2020. EPSIS was performed by using a through-the-scope catheter connected to the pressure measuring system (TR-W550, TR-TeH08, AP-C35; Keyence, Osaka, Japan) to monitor IGP. Abnormal acid reflux was defined as acid exposure time (AET) over 6.0%. Pressure waveform was characterized as follows: (i) Basal IGP, (ii) Maximum IGP, (iii) Pressure difference, (iv) Gradient of the waveform. RESULTS A total of 57 patients with GERD symptoms were analyzed. Twenty-one patients presented abnormal AET on MII-pH. Among EPSIS parameters, pressure difference during insufflation correlated with AET (ρ = -0.66, P
- Subjects :
- Insufflation
Esophageal pH Monitoring
Manometry
03 medical and health sciences
0302 clinical medicine
Japan
Gastroscopy
medicine
Cutoff
Waveform
Humans
Radiology, Nuclear Medicine and imaging
Esophagus
Retrospective Studies
business.industry
Stomach
Gastroenterology
Reflux
Area under the curve
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
GERD
Gastroesophageal Reflux
030211 gastroenterology & hepatology
business
Nuclear medicine
Subjects
Details
- ISSN :
- 14431661
- Volume :
- 33
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy SocietyReferences
- Accession number :
- edsair.doi.dedup.....3011807ee77d66803a05bafab59157fc