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Prognostic value of immunohistochemical markers for locally advanced rectal cancer
- Source :
- Molecules, Vol 27, Iss 596, p 596 (2022), Molecules; Volume 27; Issue 3; Pages: 596
- Publication Year :
- 2022
- Publisher :
- MDPI, 2022.
-
Abstract
- The aim of this study is to reveal the potential roles of apoptosis markers (Bcl2 and p53), proliferation markers (Ki-67 and CyclD1), and the neuroendocrine marker Chromogranin A as markers for the radioresistance of rectal cancer. Statistically significant differences were found in the expression of p53, Ki-67, and Chromogranin A in groups of patients with and without a favorable prognosis after radiotherapy. The survival analysis revealed that the marker of neuroendocrine differentiation, Chromogranin A, also demonstrated a high prognostic significance, indicating a poor prognosis. Markers of proliferation and apoptosis had no prognostic value for patients who received preoperative radiotherapy. Higher Chromogranin A values were predictors of poor prognosis. The results obtained from studying the Chromogranin A expression suggest that the secretion of biologically active substances by neuroendocrine cells causes an increase in tumor aggressiveness.
- Subjects :
- Adult
Male
endocrine system
proliferation
Pharmaceutical Science
Organic chemistry
Adenocarcinoma
Analytical Chemistry
QD241-441
Neuroendocrine Cells
Drug Discovery
Biomarkers, Tumor
Humans
Cyclin D1
rectal cancer
apoptosis
radiotherapy
Chromogranin A
Physical and Theoretical Chemistry
neoplasms
Aged
Rectal Neoplasms
Middle Aged
Prognosis
Immunohistochemistry
Survival Rate
Ki-67 Antigen
Proto-Oncogene Proteins c-bcl-2
Chemistry (miscellaneous)
Molecular Medicine
Female
Tumor Suppressor Protein p53
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules, Vol 27, Iss 596, p 596 (2022), Molecules; Volume 27; Issue 3; Pages: 596
- Accession number :
- edsair.doi.dedup.....301c32ca44e18991c9afedd031bd8c0c