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Macrophage migration inhibitory factor gene -173GC polymorphism and risk of bladder cancer in southeast China: a case-control analysis
- Source :
- Molecular biology reports. 39(3)
- Publication Year :
- 2011
-
Abstract
- Inflammatory factors may promote carcinogenesis. Macrophage migration inhibitory factor (MIF), which is derived from T-cell, known as a member of the transforming growth factor-β (TGF-β) superfamily, plays an important role in the pro- and anti-inflammatory response to infection and in the etiology of bladder cancer. We hypothesized that MIF-173 locus polymorphism might contribute to genetic susceptibility to bladder cancer. In a hospital-based case–control study of 325 patients with bladder cancer and 345 cancer-free controls frequency-matched by age, sex, smoking status, and alcohol use, we genotyped the MIF polymorphism and analyzed immunohistochemical stained operational bladder cancer tissue sections for MIF. We found that individuals with GC/CC genotype had a significantly decreased risk of bladder cancer (adjusted OR = 0.57, 95% CI, 0.41–0.79) than those with GG genotype. In the stratification analysis, we found that the decreased risk was more pronounced among older subjects (adjusted OR = 0.56, 95% CI, 0.39–0.81), men (0.47, 0.33–0.68), smokers (0.54, 0.35–0.85), and ever-drinkers (0.44, 0.27–0.71). The percentage of positive staining in the cytoplasm and nucleus in the normal and bladder cancer with CC/GC genotype tissues was higher than that of GG genotype bladder cancer tissue(39.1% vs. 75.0% in strong staining for GG and GC/CC genotypes, respectively, P = 0.028). In conclusion, MIF -173G>C polymorphism may play a role in the etiology of bladder cancer in southern Chinese population. Large studies are warranted to validate our findings.
- Subjects :
- Male
medicine.medical_specialty
China
Genotype
Population
Biology
medicine.disease_cause
Gastroenterology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Risk Factors
Internal medicine
Genetics
medicine
Genetic predisposition
Odds Ratio
Humans
Genetic Predisposition to Disease
education
Molecular Biology
Macrophage Migration-Inhibitory Factors
Genetic Association Studies
DNA Primers
education.field_of_study
Bladder cancer
General Medicine
medicine.disease
Immunohistochemistry
Intramolecular Oxidoreductases
Urinary Bladder Neoplasms
Case-Control Studies
Immunology
Etiology
Macrophage migration inhibitory factor
Female
Carcinogenesis
Polymorphism, Restriction Fragment Length
Subjects
Details
- ISSN :
- 15734978
- Volume :
- 39
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Molecular biology reports
- Accession number :
- edsair.doi.dedup.....302002471c5e252586bbaffd1a6f190b